Polygenic risk for alcohol misuse is moderated by romantic partnerships

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Barr , P B , Kuo , S I-C , Aliev , F , Latvala , A , Viken , R , Rose , R J , Kaprio , J , Salvatore , J E & Dick , D M 2019 , ' Polygenic risk for alcohol misuse is moderated by romantic partnerships ' , Addiction , vol. 114 , no. 10 , pp. 1753-1762 . https://doi.org/10.1111/add.14712

Title: Polygenic risk for alcohol misuse is moderated by romantic partnerships
Author: Barr, Peter B.; Kuo, Sally I-Chun; Aliev, Fazil; Latvala, Antti; Viken, Richard; Rose, Richard J.; Kaprio, Jaakko; Salvatore, Jessica E.; Dick, Danielle M.
Contributor organization: Staff Services
Institute for Molecular Medicine Finland
Department of Public Health
University of Helsinki
Genetic Epidemiology
Date: 2019-10
Language: eng
Number of pages: 10
Belongs to series: Addiction
ISSN: 0965-2140
DOI: https://doi.org/10.1111/add.14712
URI: http://hdl.handle.net/10138/312958
Abstract: Background and Aims Previous twin research suggests relationship status can moderate underlying genetic liability towards alcohol misuse. This paper examined: (1) whether genome-wide polygenic scores (GPS) for alcohol consumption are associated with alcohol misuse; (2) whether these GPS are moderated by romantic relationships (gene-environment interaction; G x E) and (3) whether G x E results are consistent across sex. Design Linear mixed-effects models were used to test associations between genome-wide polygenic scores, relationship status and alcohol use/misuse. Setting Finnish twins born between 1983 and 1987 identified through Finland's central population registry. Participants An intensively studied subset of Finnish Twin Study (FinnTwin12) during the young adult phase (aged 20-26 years). The analytical sample includes those with complete interview and genetic data (n = 1201). Measurements Key measurements included involvement in a romantic partnership, drinking frequency, intoxication frequency and DSM-IV alcohol dependence (AD) symptoms. Genome-wide polygenic scores (GPS) were created from available summary statistics from a large genome-wide association study (GWAS) of drinks per week. Results GPS predicted drinking frequency [b = 0.109; 95% confidence interval (CI) = 0.050, 0.168], intoxication frequency (b = 0.111; 95% CI = 0.054, 0.168) and AD symptoms (b = 0.123; 95% CI = 0.064, 0.182). Having a romantic relationship negatively influenced the association between GPS and drinking frequency (b = -0.105; 95% CI = -0.211, -0.001), intoxication frequency (b = -0.118; 95% CI = -0.220, -0.016) and AD symptoms (b = -0.119; 95% CI = -0.229, -0.009). There was a three-way interaction between sex, relationship status and GPS for intoxication frequency (b = 0.223; 95% CI = 0.013, 0.433), such that the reduced association between GPS and intoxication frequency for those in a relationship was only apparent in males. We found no evidence of three-way interactions for drinking frequency or AD symptoms. Conclusions Being in a romantic relationship reduced the association between genetic predisposition and drinking, high-risk drinking and alcohol problems. However, for high-risk drinking the protective effect was limited to males, mapping onto earlier findings suggesting that males benefit more from romantic partnerships.
Subject: Alcohol misuse
gene-environment interaction
polygenic risk scores
romantic partnerships
sex differences
young adulthood
3124 Neurology and psychiatry
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion

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