A biodiversity hypothesis

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http://hdl.handle.net/10138/312960

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Haahtela , T 2019 , ' A biodiversity hypothesis ' , Allergy : European journal of allergy and clinical immunology , vol. 74 , no. 8 , pp. 1445-1456 . https://doi.org/10.1111/all.13763

Title: A biodiversity hypothesis
Author: Haahtela, Tari
Contributor: University of Helsinki, HUS Inflammation Center
Date: 2019-08
Language: eng
Number of pages: 12
Belongs to series: Allergy : European journal of allergy and clinical immunology
ISSN: 0105-4538
URI: http://hdl.handle.net/10138/312960
Abstract: Biodiversity hypothesis states that contact with natural environments enriches the human microbiome, promotes immune balance and protects from allergy and inflammatory disorders. We are protected by two nested layers of biodiversity, microbiota of the outer layer (soil, natural waters, plants, animals) and inner layer (gut, skin, airways). The latter inhabits our body and is colonized from the outer layer. Explosion of human populations along with cultural evolution is profoundly changing our environment and lifestyle. Adaptive immunoregulatory circuits and dynamic homeostasis are at stake in the newly emerged urban surroundings. In allergy, and chronic inflammatory disorders in general, exploring the determinants of immunotolerance is the key for prevention and more effective treatment. Loss of immunoprotective factors, derived from nature, is a new kind of health risk poorly acknowledged until recently. The paradigm change has been implemented in the Finnish allergy programme (2008-2018), which emphasized tolerance instead of avoidance. The first results are promising, as allergy burden has started to reduce. The rapidly urbanizing world is facing serious biodiversity loss with global warming, which are interconnected. Biodiversity hypothesis of health and disease has societal impact, for example, on city planning, food and energy production and nature conservation. It has also a message for individuals for health and well-being: take nature close, to touch, eat, breathe, experience and enjoy. Biodiverse natural environments are dependent on planetary health, which should be a priority also among health professionals.
Subject: asthma
biodiversity
hygiene hypothesis
immune tolerance
microbiome
ALLERGY PROGRAM 2008-2018
99TH DAHLEM CONFERENCE
ENVIRONMENTAL MICROORGANISMS
ATOPIC SENSITIZATION
CHILDHOOD ASTHMA
HUMAN MICROBIOTA
INNATE IMMUNITY
GUT MICROBIOME
GREEN SPACE
OLD FRIENDS
3121 General medicine, internal medicine and other clinical medicine
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