Imatinib mesylate does not counteract ovarian tissue fibrosis in postnatal rat ovary

Show full item record



Permalink

http://hdl.handle.net/10138/312985

Citation

Asadi-Azarbaijani , B , Braber , S , van Duursen , M , Jahnukainen , K , Santos , R & Oskam , I C 2019 , ' Imatinib mesylate does not counteract ovarian tissue fibrosis in postnatal rat ovary ' , Reproductive Biology , vol. 19 , no. 2 , pp. 133-138 . https://doi.org/10.1016/j.repbio.2019.03.003

Title: Imatinib mesylate does not counteract ovarian tissue fibrosis in postnatal rat ovary
Author: Asadi-Azarbaijani, Babak; Braber, Saskia; van Duursen, Majorie; Jahnukainen, Kirsi; Santos, Regiane; Oskam, Irma C.
Other contributor: University of Helsinki, HUS Children and Adolescents


Date: 2019-06
Language: eng
Number of pages: 6
Belongs to series: Reproductive Biology
ISSN: 1642-431X
DOI: https://doi.org/10.1016/j.repbio.2019.03.003
URI: http://hdl.handle.net/10138/312985
Abstract: Chemotherapy may result in ovarian atrophy, a depletion of the primordial follicle pool, diminished ovarian weight, cortical and stromal fibrosis. Imatinib mesylate is an anticancer agent that inhibits competitively several receptor tyrosine kinases (RTKs). RTKs play important roles in cell metabolism, proliferation, and apoptosis. In clinic, imatinib mesylate is also known as an anti-fibrotic medicine. In the present study, the impact of imatinib on the ovarian tissue was investigated by assessing ovarian tissue fibrosis in postnatal rat administered with or without imatinib for three days. Fibrosis in the ovarian tissue was determined by histology (Picrosirius and Masson's trichrome staining) and the protein expression of vimentin and alpha-smooth muscle actin (alpha-SMA). Furthermore, mRNA expression of Forkhead box transcription factor O1 and O3 (FOXO1 and FOXO3), which are markers of cell proliferation was quantified. A short-term exposure to imatinib showed to increase tissue fibrosis in ovaries. This was observed by Masson's trichrome staining. Exposure to imatinib led also to a down-regulation of vimentin protein expression and up-regulation mRNA expression of FOXO3. This may indicate a role of FOXO3 in ovarian tissue fibrosis in postnatal rat ovaries.
Subject: 3111 Biomedicine
IMATINIB
Tissue fibrosis
OVARY
FOXO1
FOXO3
Imatinib
Tissue fibrosis
Ovary
FOXO1
FOXO3
RECEPTOR TYROSINE KINASES
C-KIT
TRANSCRIPTION FACTORS
MECHANISMS
ACTIVATION
INHIBITION
CHEMOTHERAPY
GROWTH
TRANSDIFFERENTIATION
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Imatinib_mesyla ... in_postnatal_rat_ovary.pdf 1.246Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record