Comparative fertility and pregnancy outcomes after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer : protocol for a systematic review and network meta-analysis from the CIRCLE group

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Athanasiou , A , Veroniki , A A , Efthimiou , O , Kalliala , I , Naci , H , Bowden , S , Paraskevaidi , M , Martin-Hirsch , P , Bennett , P , Paraskevaidis , E , Salanti , G & Kyrgiou , M 2019 , ' Comparative fertility and pregnancy outcomes after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer : protocol for a systematic review and network meta-analysis from the CIRCLE group ' , BMJ Open , vol. 9 , no. 10 , 028009 . https://doi.org/10.1136/bmjopen-2018-028009

Title: Comparative fertility and pregnancy outcomes after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer : protocol for a systematic review and network meta-analysis from the CIRCLE group
Author: Athanasiou, Antonios; Veroniki, Areti Angeliki; Efthimiou, Orestis; Kalliala, Ilkka; Naci, Huseyin; Bowden, Sarah; Paraskevaidi, Maria; Martin-Hirsch, Pierre; Bennett, Philip; Paraskevaidis, Evangelos; Salanti, Georgia; Kyrgiou, Maria
Contributor: University of Helsinki, Clinicum
Date: 2019-10
Language: eng
Number of pages: 7
Belongs to series: BMJ Open
ISSN: 2044-6055
URI: http://hdl.handle.net/10138/313007
Abstract: Introduction There are several local treatment methods for cervical intraepithelial neoplasia that remove or ablate a cone-shaped part of the uterine cervix. There is evidence to suggest that these increase the risk of preterm birth (PTB) and that this is higher for techniques that remove larger parts of the cervix, although the data are conflicting. We present a protocol for a systematic review and network meta-analysis (NMA) that will update the evidence and compare all treatments in terms of fertility and pregnancy complications. Methods and analysis We will search electronic databases (CENTRAL, MEDLINE, EMBASE) from inception till October 2019, in order to identify randomised controlled trials (RCTs) and cohort studies comparing the fertility and pregnancy outcomes among different excisional and ablative treatment techniques and/or to untreated controls. The primary outcome will be PTB ( Ethics and dissemination Ethical approval is not required. Results will be disseminated to academic beneficiaries, medical practitioners, patients and the public.
Subject: ELECTROSURGICAL EXCISION PROCEDURE
MULTIPLE-TREATMENTS
PRETERM BIRTH
RISK
HETEROGENEITY
INCONSISTENCY
PROPORTION
TRIALS
3123 Gynaecology and paediatrics
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