Comparative fertility and pregnancy outcomes after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer : protocol for a systematic review and network meta-analysis from the CIRCLE group

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Pysyväisosoite

http://hdl.handle.net/10138/313007

Lähdeviite

Athanasiou , A , Veroniki , A A , Efthimiou , O , Kalliala , I , Naci , H , Bowden , S , Paraskevaidi , M , Martin-Hirsch , P , Bennett , P , Paraskevaidis , E , Salanti , G & Kyrgiou , M 2019 , ' Comparative fertility and pregnancy outcomes after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer : protocol for a systematic review and network meta-analysis from the CIRCLE group ' , BMJ Open , vol. 9 , no. 10 , 028009 . https://doi.org/10.1136/bmjopen-2018-028009

Julkaisun nimi: Comparative fertility and pregnancy outcomes after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer : protocol for a systematic review and network meta-analysis from the CIRCLE group
Tekijä: Athanasiou, Antonios; Veroniki, Areti Angeliki; Efthimiou, Orestis; Kalliala, Ilkka; Naci, Huseyin; Bowden, Sarah; Paraskevaidi, Maria; Martin-Hirsch, Pierre; Bennett, Philip; Paraskevaidis, Evangelos; Salanti, Georgia; Kyrgiou, Maria
Tekijän organisaatio: Clinicum
Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
University of Helsinki
Päiväys: 2019-10
Kieli: eng
Sivumäärä: 7
Kuuluu julkaisusarjaan: BMJ Open
ISSN: 2044-6055
DOI-tunniste: https://doi.org/10.1136/bmjopen-2018-028009
URI: http://hdl.handle.net/10138/313007
Tiivistelmä: Introduction There are several local treatment methods for cervical intraepithelial neoplasia that remove or ablate a cone-shaped part of the uterine cervix. There is evidence to suggest that these increase the risk of preterm birth (PTB) and that this is higher for techniques that remove larger parts of the cervix, although the data are conflicting. We present a protocol for a systematic review and network meta-analysis (NMA) that will update the evidence and compare all treatments in terms of fertility and pregnancy complications. Methods and analysis We will search electronic databases (CENTRAL, MEDLINE, EMBASE) from inception till October 2019, in order to identify randomised controlled trials (RCTs) and cohort studies comparing the fertility and pregnancy outcomes among different excisional and ablative treatment techniques and/or to untreated controls. The primary outcome will be PTB ( Ethics and dissemination Ethical approval is not required. Results will be disseminated to academic beneficiaries, medical practitioners, patients and the public.
Avainsanat: ELECTROSURGICAL EXCISION PROCEDURE
MULTIPLE-TREATMENTS
PRETERM BIRTH
RISK
HETEROGENEITY
INCONSISTENCY
PROPORTION
TRIALS
3123 Gynaecology and paediatrics
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


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