Comparative fertility and pregnancy outcomes after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer : protocol for a systematic review and network meta-analysis from the CIRCLE group

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dc.contributor.author Athanasiou, Antonios
dc.contributor.author Veroniki, Areti Angeliki
dc.contributor.author Efthimiou, Orestis
dc.contributor.author Kalliala, Ilkka
dc.contributor.author Naci, Huseyin
dc.contributor.author Bowden, Sarah
dc.contributor.author Paraskevaidi, Maria
dc.contributor.author Martin-Hirsch, Pierre
dc.contributor.author Bennett, Philip
dc.contributor.author Paraskevaidis, Evangelos
dc.contributor.author Salanti, Georgia
dc.contributor.author Kyrgiou, Maria
dc.date.accessioned 2020-03-05T07:14:01Z
dc.date.available 2020-03-05T07:14:01Z
dc.date.issued 2019-10
dc.identifier.citation Athanasiou , A , Veroniki , A A , Efthimiou , O , Kalliala , I , Naci , H , Bowden , S , Paraskevaidi , M , Martin-Hirsch , P , Bennett , P , Paraskevaidis , E , Salanti , G & Kyrgiou , M 2019 , ' Comparative fertility and pregnancy outcomes after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer : protocol for a systematic review and network meta-analysis from the CIRCLE group ' , BMJ Open , vol. 9 , no. 10 , 028009 . https://doi.org/10.1136/bmjopen-2018-028009
dc.identifier.other PURE: 133162751
dc.identifier.other PURE UUID: 959fad37-3988-4960-b88c-5621187e997c
dc.identifier.other WOS: 000512882200043
dc.identifier.other ORCID: /0000-0002-7664-0587/work/70947214
dc.identifier.uri http://hdl.handle.net/10138/313007
dc.description.abstract Introduction There are several local treatment methods for cervical intraepithelial neoplasia that remove or ablate a cone-shaped part of the uterine cervix. There is evidence to suggest that these increase the risk of preterm birth (PTB) and that this is higher for techniques that remove larger parts of the cervix, although the data are conflicting. We present a protocol for a systematic review and network meta-analysis (NMA) that will update the evidence and compare all treatments in terms of fertility and pregnancy complications. Methods and analysis We will search electronic databases (CENTRAL, MEDLINE, EMBASE) from inception till October 2019, in order to identify randomised controlled trials (RCTs) and cohort studies comparing the fertility and pregnancy outcomes among different excisional and ablative treatment techniques and/or to untreated controls. The primary outcome will be PTB ( Ethics and dissemination Ethical approval is not required. Results will be disseminated to academic beneficiaries, medical practitioners, patients and the public. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof BMJ Open
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject ELECTROSURGICAL EXCISION PROCEDURE
dc.subject MULTIPLE-TREATMENTS
dc.subject PRETERM BIRTH
dc.subject RISK
dc.subject HETEROGENEITY
dc.subject INCONSISTENCY
dc.subject PROPORTION
dc.subject TRIALS
dc.subject 3123 Gynaecology and paediatrics
dc.title Comparative fertility and pregnancy outcomes after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer : protocol for a systematic review and network meta-analysis from the CIRCLE group en
dc.type Review Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of Obstetrics and Gynecology
dc.contributor.organization HUS Gynecology and Obstetrics
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1136/bmjopen-2018-028009
dc.relation.issn 2044-6055
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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