Gas-foamed poly(lactide-co-glycolide) and poly(lactide-co-glycolide) with bioactive glass fibres demonstrate insufficient bone repair in lapine osteochondral defects

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Salonius , E , Muhonen , V , Lehto , K , Järvinen , E , Pyhältö , T , Hannula , M , Aula , A S , Uppstu , P , Haaparanta , A-M , Rosling , A , Kellomäki , M & Kiviranta , I 2019 , ' Gas-foamed poly(lactide-co-glycolide) and poly(lactide-co-glycolide) with bioactive glass fibres demonstrate insufficient bone repair in lapine osteochondral defects ' , Journal of Tissue Engineering and Regenerative Medicine , vol. 13 , no. 3 , pp. 406-415 . https://doi.org/10.1002/term.2801

Title: Gas-foamed poly(lactide-co-glycolide) and poly(lactide-co-glycolide) with bioactive glass fibres demonstrate insufficient bone repair in lapine osteochondral defects
Author: Salonius, Eve; Muhonen, Virpi; Lehto, Kalle; Järvinen, Elina; Pyhältö, Tuomo; Hannula, Markus; Aula, Antti S.; Uppstu, Peter; Haaparanta, Anne-Marie; Rosling, Ari; Kellomäki, Minna; Kiviranta, Ilkka
Contributor: University of Helsinki, I kirurgian klinikka (Töölö)
University of Helsinki, Department of Surgery
University of Helsinki, Clinicum
University of Helsinki, I kirurgian klinikka (Töölö)
University of Helsinki, Department of Surgery
Date: 2019-03
Language: eng
Number of pages: 10
Belongs to series: Journal of Tissue Engineering and Regenerative Medicine
ISSN: 1932-6254
URI: http://hdl.handle.net/10138/313014
Abstract: Deep osteochondral defects may leave voids in the subchondral bone, increasing the risk of joint structure collapse. To ensure a stable foundation for the cartilage repair, bone grafts can be used for filling these defects. Poly(lactide-co-glycolide) (PLGA) is a biodegradable material that improves bone healing and supports bone matrix deposition. We compared the reparative capacity of two investigative macroporous PLGA-based biomaterials with two commercially available bone graft substitutes in the bony part of an intra-articular bone defect created in the lapine femur. New Zealand white rabbits (n = 40) were randomized into five groups. The defects, 4 mm in diameter and 8 mm deep, were filled with neat PLGA; a composite material combining PLGA and bioactive glass fibres (PLGA-BGf); commercial beta-tricalcium phosphate (beta-TCP) granules; or commercial bioactive glass (BG) granules. The fifth group was left untreated for spontaneous repair. After three months, the repair tissue was evaluated with X-ray microtomography and histology. Relative values comparing the operated knee with its contralateral control were calculated. The relative bone volume fraction ( increment BV/TV) was largest in the beta-TCP group (p
Subject: animal model
biomaterial
bone repair
intra-articular
poly(lactide-co-glycolide)
BETA-TRICALCIUM PHOSPHATE
ARTICULAR-CARTILAGE
POROUS SCAFFOLDS
AUTOGENOUS BONE
TISSUE
RABBIT
MODEL
REGENERATION
SUBSTITUTES
STABILITY
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
318 Medical biotechnology
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