Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages

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http://hdl.handle.net/10138/313016

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Suh , S H , Choe , K , Hong , S P , Jeong , S , Mäkinen , T , Kim , K S , Alitalo , K , Surh , C D , Koh , G Y & Song , J-H 2019 , ' Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages ' , EMBO Reports , vol. 20 , no. 4 , 46927 . https://doi.org/10.15252/embr.201846927

Title: Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages
Author: Suh, Sang Heon; Choe, Kibaek; Hong, Seon Pyo; Jeong, Seung-hwan; Mäkinen, Taija; Kim, Kwang Soon; Alitalo, Kari; Surh, Charles D.; Koh, Gou Young; Song, Joo-Hye
Contributor: University of Helsinki, HUSLAB
Date: 2019-04
Language: eng
Number of pages: 20
Belongs to series: EMBO Reports
ISSN: 1469-221X
URI: http://hdl.handle.net/10138/313016
Abstract: A lacteal is a blunt-ended, long, tube-like lymphatic vessel located in the center of each intestinal villus that provides a unique route for drainage of absorbed lipids from the small intestine. However, key regulators for maintaining lacteal integrity are poorly understood. Here, we explore whether and how the gut microbiota regulates lacteal integrity. Germ depletion by antibiotic treatment triggers lacteal regression during adulthood and delays lacteal maturation during the postnatal period. In accordance with compromised lipid absorption, the button-like junction between lymphatic endothelial cells, which is ultrastructurally open to permit free entry of dietary lipids into lacteals, is significantly reduced in lacteals of germ-depleted mice. Lacteal defects are also found in germ-free mice, but conventionalization of germ-free mice leads to normalization of lacteals. Mechanistically, VEGF-C secreted from villus macrophages upon MyD88-dependent recognition of microbes and their products is a main factor in lacteal integrity. Collectively, we conclude that the gut microbiota is a crucial regulator for lacteal integrity by endowing its unique microenvironment and regulating villus macrophages in small intestine.
Subject: intestinal lymphatic vasculature
lacteal
macrophage
microbiota
VEGF-C
DEPENDENT STIMULATION
LYMPHATIC VESSELS
GERM-FREE
IMMUNE
INNATE
CELLS
LYMPHANGIOGENESIS
INFLAMMATION
REGENERATION
BACTERIA
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
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