Does Evaluation of Tumour Budding in Diagnostic Biopsies have a Clinical Relevance? : A Systematic Review

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Almangush , A , Youssef , O , Pirinen , M , Sundström , J , Leivo , I & Mäkitie , A A 2019 , ' Does Evaluation of Tumour Budding in Diagnostic Biopsies have a Clinical Relevance? A Systematic Review ' , Histopathology , vol. 74 , no. 4 , pp. 536-544 . https://doi.org/10.1111/his.13793 , https://doi.org/10.1111/his.13793

Title: Does Evaluation of Tumour Budding in Diagnostic Biopsies have a Clinical Relevance? : A Systematic Review
Author: Almangush, Alhadi; Youssef, Omar; Pirinen, Matti; Sundström, Jari; Leivo, Ilmo; Mäkitie, Antti A.
Contributor: University of Helsinki, Department of Pathology
University of Helsinki, Department of Pathology
University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
Date: 2019-03
Language: eng
Number of pages: 9
Belongs to series: Histopathology
ISSN: 0309-0167
URI: http://hdl.handle.net/10138/313081
Abstract: Tumour budding has emerged as a promising prognostic marker in many cancers. We systematically reviewed all studies that evaluated tumour budding in diagnostic biopsies. We conducted a systematic review of PubMed, MEDLINE, Scopus, Web of Science and Cochrane library for all articles that have assessed tumour budding in diagnostic (i.e. pretreatment or pre-operative) biopsies of any tumour type. Two independent researchers screened the retrieved studies, removed duplicates, excluded irrelevant studies and extracted data from the eligible studies. A total of 13 reports comprising 11 cohorts were found to have studied tumour budding in diagnostic biopsies. All these reports showed that evaluation of tumour budding in diagnostic biopsies was easily applicable. A strong association was observed between tumour budding score in diagnostic biopsies and corresponding surgical samples. Evaluation of tumour budding in diagnostic biopsies had a significant prognostic value for lymph node metastasis and patient survival. In all studies, tumour budding was a valuable marker of tumour aggressiveness and can be evaluated in technically satisfactory diagnostic biopsies. Thus, the assessment of tumour budding seems to identify the behaviour of cancer, and therefore to facilitate treatment planning.
Subject: 111 Mathematics
3111 Biomedicine
3121 Internal medicine
BIOPSY
MARKER
PROGNOSIS
TREATMENT PLANNING
TUMOUR BUDDING
SQUAMOUS-CELL CARCINOMA
LYMPH-NODE METASTASIS
PREOPERATIVE BIOPSIES
PROGNOSTIC VALUE
POOR-PROGNOSIS
CANCER
STAGE
PREDICTS
SPECIMENS
TONGUE
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