Effect of hypoxemia on fetal ventricular deformation in a chronically instrumented sheep model

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Bhide , A , Räsänen , J , Huhta , H , Junno , J , Erkinaro , T , Ohtonen , P , Haapsamo , M & Acharya , G 2017 , ' Effect of hypoxemia on fetal ventricular deformation in a chronically instrumented sheep model ' , Ultrasound in Medicine & Biology , vol. 43 , no. 5 , pp. 967-973 . https://doi.org/10.1016/j.ultrasmedbio.2017.01.010

Title: Effect of hypoxemia on fetal ventricular deformation in a chronically instrumented sheep model
Author: Bhide, Amarnath; Räsänen, Juha; Huhta, Heikki; Junno, Juulia; Erkinaro, Tiina; Ohtonen, Pasi; Haapsamo, Mervi; Acharya, Ganesh
Contributor organization: Clinicum
Department of Obstetrics and Gynecology
Date: 2017-05
Language: eng
Number of pages: 7
Belongs to series: Ultrasound in Medicine & Biology
ISSN: 0301-5629
DOI: https://doi.org/10.1016/j.ultrasmedbio.2017.01.010
URI: http://hdl.handle.net/10138/313130
Abstract: We hypothesized that in near-term sheep fetuses, hypoxemia changes myocardial function as reflected in altered ventricular deformation on speckle-tracking echocardiography. Fetuses in 21 pregnant sheep were instrumented. After 4 d of recovery, fetal cardiac function was assessed by echocardiography at baseline, after 30 and 120 min of induced fetal hypoxemia and after its reversal. Left (LV) and right (RV) ventricular cardiac output and myocardial strain were measured. Baseline mean (standard deviation [ SD]) LV and RV global longitudinal strains were -18.7% (3.8) and -14.3% (5.3). Baseline RV global longitudinal and circumferential deformations were less compared with those of the left ventricle (p = 0.016 and p <0.005). LV, but not RV, global longitudinal strain was decreased (p = 0.003) compared with baseline with hypoxemia. Circumferential and radial strains did not exhibit significant changes. In the near-term sheep fetus, LV global longitudinal and circumferential strains are more negative than RV strains. Acute hypoxemia leads to LV rather than RV dysfunction as reflected by decreased deformation. (C) 2017 World Federation for Ultrasound in Medicine & Biology.
Subject: Speckle-tracking echocardiography
Hypoxemia
Sheep model
SPECKLE-TRACKING ECHOCARDIOGRAPHY
PLACENTAL VASCULAR-RESISTANCE
CARDIAC-OUTPUT
STRAIN-RATE
BLOOD-FLOW
RESPONSES
ASPHYXIA
HYPOXIA
HEART
OXYGENATION
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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