Cardiac lymphatics in health and disease

Show full item record



Permalink

http://hdl.handle.net/10138/313218

Citation

Brakenhielm , E & Alitalo , K 2019 , ' Cardiac lymphatics in health and disease ' , Nature reviews. Cardiology , vol. 16 , no. 1 , pp. 56-68 . https://doi.org/10.1038/s41569-018-0087-8

Title: Cardiac lymphatics in health and disease
Author: Brakenhielm, Ebba; Alitalo, Kari
Contributor: University of Helsinki, HUSLAB
Date: 2019-01
Language: eng
Number of pages: 13
Belongs to series: Nature reviews. Cardiology
ISSN: 1759-5002
URI: http://hdl.handle.net/10138/313218
Abstract: The lymphatic vasculature, which accompanies the blood vasculature in most organs, is indispensable in the maintenance of tissue fluid homeostasis, immune cell trafficking, and nutritional lipid uptake and transport, as well as in reverse cholesterol transport. In this Review, we discuss the physiological role of the lymphatic system in the heart in the maintenance of cardiac health and describe alterations in lymphatic structure and function that occur in cardiovascular pathology, including atherosclerosis and myocardial infarction. We also briefly discuss the role that immune cells might have in the regulation of lymphatic growth (lymphangiogenesis) and function. Finally, we provide examples of how the cardiac lymphatics can be targeted therapeutically to restore lymphatic drainage in the heart to limit myocardial oedema and chronic inflammation.
Subject: GROWTH-FACTOR-D
DENDRITIC CELL-MIGRATION
MYOCARDIAL EDEMA
VEGF-C
T-CELL
TUMOR LYMPHANGIOGENESIS
ADVENTITIAL LYMPHATICS
INFLAMMATORY RESPONSE
ENDOTHELIAL-CELLS
TRANSGENIC MICE
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Alitalo_V3_revised.pdf 1.449Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record