Polysaccharides in Ocular Drug Delivery

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http://hdl.handle.net/10138/313284

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Dubashynskaya , N , Poshina , D , Raik , S , Urtti , A & Skorik , Y A 2020 , ' Polysaccharides in Ocular Drug Delivery ' , Pharmaceutics , vol. 12 , no. 1 , 22 . https://doi.org/10.3390/pharmaceutics12010022

Title: Polysaccharides in Ocular Drug Delivery
Author: Dubashynskaya, Natallia; Poshina, Daria; Raik, Sergei; Urtti, Arto; Skorik, Yury A.
Contributor: University of Helsinki, Drug Research Program
Date: 2020-01
Language: eng
Number of pages: 30
Belongs to series: Pharmaceutics
ISSN: 1999-4923
URI: http://hdl.handle.net/10138/313284
Abstract: Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies. The properties of polysaccharides can be extensively modified to optimize ocular drug formulations and to obtain biocompatible and biodegradable drugs with improved bioavailability and tailored pharmacological effects. This review discusses the available polysaccharide choices for overcoming the difficulties associated with ocular drug delivery, and it explores the reasons for the dependence between the physicochemical properties of polysaccharide-based drug carriers and their efficiency in different formulations and applications. Polysaccharides will continue to be of great interest to researchers endeavoring to develop ophthalmic drugs with improved effectiveness and safety.
Subject: eye tissue regeneration
intravitreal administration
ocular bioavailability
ocular drug delivery
periocular administration
polysaccharide
topical administration
AQUEOUS-HUMOR PHARMACOKINETICS
DRY-EYE DISEASE
HYALURONIC-ACID
IN-VITRO
CHITOSAN NANOPARTICLES
ARTIFICIAL TEARS
HYDROXYPROPYL METHYLCELLULOSE
SUBCONJUNCTIVAL INJECTION
BIOMEDICAL APPLICATIONS
TRANSSCLERAL DELIVERY
317 Pharmacy
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