Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns

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http://hdl.handle.net/10138/313289

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Sliz , E , Kalaoja , M , Ahola-Olli , A , Raitakari , O , Perola , M , Salomaa , V , Lehtimäki , T , Karhu , T , Viinamäki , H , Salmi , M , Santalahti , K , Jalkanen , S , Jokelainen , J , Keinänen-Kiukaanniemi , S , Männikkö , M , Herzig , K-H , Jarvelin , M-R , Sebert , S & Kettunen , J 2019 , ' Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns ' , Journal of Medical Genetics , vol. 56 , no. 9 , pp. 607-616 . https://doi.org/10.1136/jmedgenet-2018-105965

Title: Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns
Author: Sliz, Eeva; Kalaoja, Marita; Ahola-Olli, Ari; Raitakari, Olli; Perola, Markus; Salomaa, Veikko; Lehtimäki, Terho; Karhu, Toni; Viinamäki, Heimo; Salmi, Marko; Santalahti, Kristiina; Jalkanen, Sirpa; Jokelainen, Jari; Keinänen-Kiukaanniemi, Sirkka; Männikkö, Minna; Herzig, Karl-Heinz; Jarvelin, Marjo-Riitta; Sebert, Sylvain; Kettunen, Johannes
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
Date: 2019-09
Language: eng
Number of pages: 10
Belongs to series: Journal of Medical Genetics
ISSN: 0022-2593
URI: http://hdl.handle.net/10138/313289
Abstract: Background Inflammatory processes contribute to the pathophysiology of multiple chronic conditions. Genetic factors play a crucial role in modulating the inflammatory load, but the exact mechanisms are incompletely understood. Objective To assess genetic determinants of 16 circulating cytokines and cell adhesion molecules (inflammatory phenotypes) in Finns. Methods Genome-wide associations of the inflammatory phenotypes were studied in Northern Finland Birth Cohort 1966 (N=5284). A subsequent meta-analysis was completed for 10 phenotypes available in a previous genome-wide association study, adding up to 13 577 individuals in the study. Complementary association tests were performed to study the effect of the ABO blood types on soluble adhesion molecule levels. Results We identified seven novel and six previously reported genetic associations (p Conclusion The present results extend the knowledge about genetic factors contributing to the inflammatory load. Our findings suggest that two distinct mechanisms contribute to the soluble adhesion molecule levels in the ABO locus and that elevated soluble adhesion molecule levels per se may not increase risk for cardiovascular disease.
Subject: E-SELECTIN
INFLAMMATION
DISEASE
METAANALYSIS
ACTIVATION
EXPRESSION
VCAM-1
RISK
1184 Genetics, developmental biology, physiology
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