Aula , H , Skyttä , T , Tuohinen , S , Luukkaala , T , Hämäläinen , M , Virtanen , V , Raatikainen , P , Moilanen , E & Kellokumpu-Lehtinen , P-L 2020 , ' ST2 levels increased and were associated with changes in left ventricular systolic function during a three-year follow-up after adjuvant radiotherapy for breast cancer ' , Breast , vol. 49 , pp. 183-186 . https://doi.org/10.1016/j.breast.2019.12.001
Title: | ST2 levels increased and were associated with changes in left ventricular systolic function during a three-year follow-up after adjuvant radiotherapy for breast cancer |
Author: | Aula, Hanna; Skyttä, Tanja; Tuohinen, Suvi; Luukkaala, Tiina; Hämäläinen, Mari; Virtanen, Vesa; Raatikainen, Pekka; Moilanen, Eeva; Kellokumpu-Lehtinen, Pirkko-Liisa |
Contributor organization: | HUS Heart and Lung Center Clinicum Department of Medicine Kardiologian yksikkö |
Date: | 2020-02 |
Language: | eng |
Number of pages: | 4 |
Belongs to series: | Breast |
ISSN: | 0960-9776 |
DOI: | https://doi.org/10.1016/j.breast.2019.12.001 |
URI: | http://hdl.handle.net/10138/313367 |
Abstract: | Objectives: To search for biomarkers of RT-induced cardiotoxicity, we studied the behavior of ST2 during RT and three years after RT, and the associations with echocardiographic changes. Materials and methods: We measured soluble ST2 (ng/ml) in serum samples from 63 patients receiving RT for early breast cancer. Sampling and echocardiography were performed at baseline, after RT and at the three-year follow-up. Patients were grouped by >15% (group 1) and Results: ST2 levels tended to increase during RT, from a median (interquartile range; IQR) of 17.9 (12.4 - 22.4) at baseline to 18.2 (14.1-23.5) after RT (p = 0.075). By the three-year follow up, ST2 levels increased to 18.7 (15.8-24.2), p = 0.018. The increase in ST2 level was associated with worsening cardiac systolic function at three-year follow-up, GLS (rho = 0.272, p = 0.034) and left ventricular ejection fraction (LVEF) (rho = -0.343, p = 0.006). Group 1 (n = 14) had a significant increase in ST2 levels from 17.8 (12.3-22.5) at baseline to 18.4 (15.6-22.6) after RT, p = 0.035 and to 19.9 (16.0-25.1) three years after RT, p = 0.005. ST2 levels were stable in group 2 (n = 47): 17.8 (12.3-22.0) at baseline, 17.7 (12.6-23.5) after RT and 18.0 (15.5-22.4) at three years. Conclusion: ST2 may be useful for determining which patients are at risk for long-term cardiovascular toxicity following adjuvant breast cancer RT, but prospective clinical studies are needed to confirm this hypothesis. (C) 2019 Elsevier Ltd. |
Subject: |
ST2
Cardiotoxicity Breast cancer Radiotherapy Echocardiography Left ventricular systolic function GLOBAL LONGITUDINAL STRAIN POPULATION-BASED COHORT FAMILY-MEMBER ST2 HEART-FAILURE SOLUBLE ST2 CARDIOVASCULAR MORTALITY LUNG-CANCER DISEASE WOMEN RISK 3122 Cancers 3123 Gynaecology and paediatrics |
Peer reviewed: | Yes |
Rights: | cc_by_nc_nd |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
Total number of downloads: Loading...
Files | Size | Format | View |
---|---|---|---|
1_s2.0_S0960977619311063_main.pdf | 201.7Kb |
View/ |