Asbestos, Smoking and Lung Cancer : An Update

Show full item record



Permalink

http://hdl.handle.net/10138/313371

Citation

Klebe , S , Leigh , J , Henderson , D W & Nurminen , M 2020 , ' Asbestos, Smoking and Lung Cancer : An Update ' , International Journal of Environmental Research and Public Health , vol. 17 , no. 1 , 258 . https://doi.org/10.3390/ijerph17010258

Title: Asbestos, Smoking and Lung Cancer : An Update
Author: Klebe, Sonja; Leigh, James; Henderson, Douglas W.; Nurminen, Markku
Contributor: University of Helsinki, Department of Public Health
Date: 2020-01
Language: eng
Number of pages: 23
Belongs to series: International Journal of Environmental Research and Public Health
ISSN: 1661-7827
URI: http://hdl.handle.net/10138/313371
Abstract: This review updates the scientific literature concerning asbestos and lung cancer, emphasizing cumulative exposure and synergism between asbestos exposure and tobacco smoke, and proposes an evidence-based and equitable approach to compensation for asbestos-related lung cancer cases. This update is based on several earlier reviews written by the second and third authors on asbestos and lung cancer since 1995. We reevaluated the peer-reviewed epidemiologic studies. In addition, selected in vivo and in vitro animal studies and molecular and cellular studies in humans were included. We conclude that the mechanism of lung cancer causation induced by the interdependent coaction of asbestos fibers and tobacco smoke at a biological level is a multistage stochastic process with both agents acting conjointly at all times. The new knowledge gained through this review provides the evidence for synergism between asbestos exposure and tobacco smoke in lung cancer causation at a biological level. The evaluated statistical data conform best to a multiplicative model for the interaction effects of asbestos and smoking on the lung cancer risk, with no requirement for asbestosis. Any asbestos exposure, even in a heavy smoker, contributes to causation. Based on this information, we propose criteria for the attribution of lung cancer to asbestos in smokers and non-smokers.
Subject: asbestosis
carcinoma
cumulative exposure
mesothelioma
multiplicative model
pathogenesis
smoking
synergism
BRONCHIAL EPITHELIAL-CELLS
CHRYSOTILE ASBESTOS
HELSINKI-CRITERIA
PLEURAL PLAQUES
AMOSITE ASBESTOS
CIGARETTE-SMOKE
MALIGNANT MESOTHELIOMA
OCCUPATIONAL-EXPOSURE
CONSENSUS STATEMENT
CONFOUNDING ISSUES
3142 Public health care science, environmental and occupational health
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
ijerph_17_00258_v4.pdf 765.2Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record