Fetal chronic hypoxia and oxidative stress in diabetic pregnancy. Could fetal erythropoietin improve offspring outcomes?

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Teramo , K & Piñeiro-Ramos , J D 2019 , ' Fetal chronic hypoxia and oxidative stress in diabetic pregnancy. Could fetal erythropoietin improve offspring outcomes? ' , Free Radical Biology & Medicine , vol. 142 , pp. 32-37 . https://doi.org/10.1016/j.freeradbiomed.2019.03.012

Title: Fetal chronic hypoxia and oxidative stress in diabetic pregnancy. Could fetal erythropoietin improve offspring outcomes?
Author: Teramo, Kari; Piñeiro-Ramos, José David
Contributor: University of Helsinki, HUS Gynecology and Obstetrics
Date: 2019-10
Language: eng
Number of pages: 6
Belongs to series: Free Radical Biology & Medicine
ISSN: 0891-5849
URI: http://hdl.handle.net/10138/313431
Abstract: Oxidative stress is responsible for microvascular complications (hypertension, nephropathy, retinopathy, peripheral neuropathy) of diabetes, which during pregnancy increase both maternal and fetal complications. Chronic hypoxia and hyperglycemia result in increased oxidative stress and decreased antioxidant enzyme activity. However, oxidative stress induces also anti-oxidative reactions both in pregnant diabetes patients and in their fetuses. Not all type 1 diabetes patients with long-lasting disease develop microvascular complications, which suggests that some of these patients have protective mechanisms against these complications. Fetal erythropoietin (EPO) is the main regulator of red cell production in the mother and in the fetus, but it has also protective effects in various maternal and fetal tissues. This dual effect of EPO is based on EPO receptor (EPO-R) isoforms, which differ structurally and functionally from the hematopoietic EPO-R isoform. The tissue protective effects of EPO are based on its anti-apoptotic, anti-oxidative, anti-inflammatory, cell proliferative and angiogenic properties. Recent experimental and clinical studies have shown that EPO has also positive metabolic effects on hyperglycemia and diabetes, although these have not yet been fully delineated. Whether the tissue protective and metabolic effects of EPO could have clinical benefits, are important topics for future research in diabetic pregnancies.
Subject: Fetus
Chronic hypoxia
Oxidative stress
Diabetes mellitus
Pregnancy
Erythropoietin
MOTHERS
GLYCEMIC CONTROL
ACTIVATION
AMNIOTIC-FLUID
OXYGEN
WOMEN
MUSCLE INSULIN-RESISTANCE
INFANTS
GROWTH
TYPE-1
3123 Gynaecology and paediatrics
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
3121 General medicine, internal medicine and other clinical medicine
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