Influence of the intestinal microbiota on disease susceptibility in kittens with experimentally-induced carriage of atypical enteropathogenic Escherichia coli

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dc.contributor.author Watson, Victoria E.
dc.contributor.author Jacob, Megan E.
dc.contributor.author Bruno-Bárcena, José M.
dc.contributor.author Amirsultan, Sophia
dc.contributor.author Stauffer, Stephen H.
dc.contributor.author Píqueras, Victoria O.
dc.contributor.author Frias, Rafael
dc.contributor.author Gookin, Jody L.
dc.date.accessioned 2020-03-18T03:24:21Z
dc.date.available 2021-12-17T22:45:50Z
dc.date.issued 2019-04
dc.identifier.citation Watson , V E , Jacob , M E , Bruno-Bárcena , J M , Amirsultan , S , Stauffer , S H , Píqueras , V O , Frias , R & Gookin , J L 2019 , ' Influence of the intestinal microbiota on disease susceptibility in kittens with experimentally-induced carriage of atypical enteropathogenic Escherichia coli ' , Veterinary Microbiology , vol. 231 , pp. 197-206 . https://doi.org/10.1016/j.vetmic.2019.03.020
dc.identifier.other PURE: 123367009
dc.identifier.other PURE UUID: 7906fd7d-df2c-47f7-ad37-38c1defcb473
dc.identifier.other RIS: urn:90337F2B4FEC932FAB48B390BC2DE64A
dc.identifier.other WOS: 000466621400030
dc.identifier.uri http://hdl.handle.net/10138/313432
dc.description.abstract Typical enteropathogenic E. coli (tEPEC) carries the highest hazard of death in children with diarrhea and atypical EPEC (aEPEC) was recently identified as significantly associated with diarrheal mortality in kittens. In both children and kittens there is a significant association between aEPEC burden and diarrheal disease, however the infection can be found in individuals with and without diarrhea. It remains unclear to what extent, under what conditions, or by what mechanisms aEPEC serves as a primary pathogen in individuals with diarrhea. It seems likely that a combination of host and bacterial factors enable aEPEC to cause disease in some individuals and not in others. The purpose of this study was to determine the impact of aEPEC on intestinal function and diarrhea in kittens following experimentally-induced carriage and the influence of a disrupted intestinal microbiota on disease susceptibility. Results of this study identify aEPEC as a potential pathogen in kittens. In the absence of disruption to the intestinal microbiota, kittens are resistant to clinical signs of aEPEC carriage but demonstrate significant occult changes in intestinal absorption and permeability. Antibiotic-induced disruption of the intestinal microbiota prior to infection increases subsequent intestinal water loss as determined by % fecal wet weight. Enrichment of the intestinal microbiota with a commensal member of the feline mucosa-associated microbiota, Enterococcus hirae, ameliorated the effects of aEPEC experimental infection on intestinal function and water loss. These observations begin to unravel the mechanisms by which aEPEC infection may be able to exploit susceptible hosts. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Veterinary Microbiology
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Animal model
dc.subject CONTRIBUTE
dc.subject DIARRHEA
dc.subject ENTEROCOCCUS-HIRAE
dc.subject Enterococcus hirae
dc.subject Feline
dc.subject HEALTHY
dc.subject INFECTION
dc.subject MECHANISM
dc.subject MORTALITY
dc.subject PERMEABILITY
dc.subject Probiotic
dc.subject TRANSPORT
dc.subject XYLOSE
dc.subject aEPEC
dc.subject 413 Veterinary science
dc.title Influence of the intestinal microbiota on disease susceptibility in kittens with experimentally-induced carriage of atypical enteropathogenic Escherichia coli en
dc.type Article
dc.contributor.organization Departments of Faculty of Veterinary Medicine
dc.contributor.organization Faculty of Veterinary Medicine
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.vetmic.2019.03.020
dc.relation.issn 0378-1135
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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