IGEMS : The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update

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Pedersen , N L , Gatz , M , Finch , B K , Finkel , D , Butler , D A , Dahl Aslan , A , Franz , C E , Kaprio , J , Lapham , S , McGue , M , Mosing , M A , Neiderhiser , J , Nygaard , M , Panizzon , M , Prescott , C A , Reynolds , C A , Sachdev , P & Whitfield , K E 2019 , ' IGEMS : The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update ' , Twin Research and Human Genetics , vol. 22 , no. 6 , 1832427419000768 , pp. 809-816 . https://doi.org/10.1017/thg.2019.76

Title: IGEMS : The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update
Author: Pedersen, Nancy L.; Gatz, Margaret; Finch, Brian K.; Finkel, Deborah; Butler, David A.; Dahl Aslan, Anna; Franz, Carol E.; Kaprio, Jaakko; Lapham, Susan; McGue, Matt; Mosing, Miriam A.; Neiderhiser, Jenae; Nygaard, Marianne; Panizzon, Matthew; Prescott, Carol A.; Reynolds, Chandra A.; Sachdev, Perminder; Whitfield, Keith E.
Contributor organization: Institute for Molecular Medicine Finland
Department of Public Health
Faculty of Medicine
University of Helsinki
Helsinki Institute of Life Science HiLIFE
Date: 2019-12
Language: eng
Number of pages: 8
Belongs to series: Twin Research and Human Genetics
ISSN: 1832-4274
DOI: https://doi.org/10.1017/thg.2019.76
URI: http://hdl.handle.net/10138/313459
Abstract: The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countries (Sweden, Denmark, Finland, United States, and Australia) established to explore the nature of gene-environment (GE) interplay in functioning across the adult lifespan. Fifteen of the studies are longitudinal, with follow-up as long as 59 years after baseline. The combined data from over 76,000 participants aged 14-103 at intake (including over 10,000 monozygotic and over 17,000 dizygotic twin pairs) support two primary research emphases: (1) investigation of models of GE interplay of early life adversity, and social factors at micro and macro environmental levels and with diverse outcomes, including mortality, physical functioning and psychological functioning; and (2) improved understanding of risk and protective factors for dementia by incorporating unmeasured and measured genetic factors with a wide range of exposures measured in young adulthood, midlife and later life.
Subject: Dementia
early life adversity
gene-environment interplay
socioeconomic status
1184 Genetics, developmental biology, physiology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion

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