The Nordic Twin Study on Cancer - NorTwinCan

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dc.contributor.author Nordic Twin Study Canc NorTwinCan
dc.contributor.author Harris, Jennifer R.
dc.contributor.author Hjelmborg, Jacob
dc.contributor.author Adami, Hans-Olov
dc.contributor.author Czene, Kamila
dc.contributor.author Mucci, Lorelei
dc.contributor.author Kaprio, Jaakko
dc.date.accessioned 2020-03-19T13:12:12Z
dc.date.available 2020-03-19T13:12:12Z
dc.date.issued 2019-12
dc.identifier.citation Nordic Twin Study Canc NorTwinCan , Harris , J R , Hjelmborg , J , Adami , H-O , Czene , K , Mucci , L & Kaprio , J 2019 , ' The Nordic Twin Study on Cancer - NorTwinCan ' , Twin Research and Human Genetics , vol. 22 , no. 6 , 1832427419000719 , pp. 817-823 . https://doi.org/10.1017/thg.2019.71
dc.identifier.other PURE: 133880135
dc.identifier.other PURE UUID: 403e9d21-f77f-45e2-be0a-f0bf111bb7cd
dc.identifier.other WOS: 000517442200062
dc.identifier.uri http://hdl.handle.net/10138/313466
dc.description.abstract Nordic twin studies have played a critical role in understanding cancer etiology and elucidating the nature of familial effects on site-specific cancers. The NorTwinCan consortium is a collaborative effort that capitalizes on unique research advantages made possible through the Nordic system of registries. It was constructed by linking the population-based twin registries of Denmark, Finland, Norway and Sweden to their country-specific national cancer and cause-of-death registries. These linkages enable the twins to be followed many decades for cancer incidence and mortality. To date, two major linkages have been conducted: NorTwinCan I in 2011-2012 and NorTwinCan II in 2018. Overall, there are 315,413 eligible twins, 57,236 incident cancer cases and 58 years of follow-up, on average. In the initial phases of our work, NorTwinCan established the world's most comprehensive twin database for studying cancer, developed novel analytical approaches tailored to address specific research considerations within the context of the Nordic data and leveraged these models and data in research publications that provide the most accurate estimates of heritability and familial risk of cancers reported in the literature to date. Our findings indicate an excess familial risk for nearly all cancers and demonstrate that the incidence of cancer among twins mirrors the rate in the general population. They also revealed that twin concordance for cancer most often manifests across, rather than within, cancer sites, and we are currently focusing on the analysis of these cross-cancer associations. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Twin Research and Human Genetics
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Twins
dc.subject cancer
dc.subject NorTwinCan
dc.subject FAMILIAL RISK
dc.subject COLORECTAL-CANCER
dc.subject HERITABILITY
dc.subject CONCORDANCE
dc.subject DENMARK
dc.subject PAGE
dc.subject 1184 Genetics, developmental biology, physiology
dc.subject 3122 Cancers
dc.subject 3142 Public health care science, environmental and occupational health
dc.title The Nordic Twin Study on Cancer - NorTwinCan en
dc.type Article
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Department of Public Health
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1017/thg.2019.71
dc.relation.issn 1832-4274
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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