Genetic analyses of Seoul hantavirus genome recovered from rats (Rattus norvegicus) in the Netherlands unveils diverse routes of spread into Europe

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Ling , J , Verner-Carlsson , J , Eriksson , P , Plyusnina , A , Loehmus , M , Jaerhult , J D , van de Goot , F , Plyusnin , A , Lundkvist , A & Sironen , T 2019 , ' Genetic analyses of Seoul hantavirus genome recovered from rats (Rattus norvegicus) in the Netherlands unveils diverse routes of spread into Europe ' , Journal of Medical Virology , vol. 91 , no. 5 , pp. 724-730 . https://doi.org/10.1002/jmv.25390

Title: Genetic analyses of Seoul hantavirus genome recovered from rats (Rattus norvegicus) in the Netherlands unveils diverse routes of spread into Europe
Author: Ling, Jiaxin; Verner-Carlsson, Jenny; Eriksson, Per; Plyusnina, Angelina; Loehmus, Mare; Jaerhult, Josef D.; van de Goot, Frank; Plyusnin, Alexander; Lundkvist, Ake; Sironen, Tarja
Contributor organization: Department of Virology
Medicum
Emerging Infections Research Group
Date: 2019-05
Language: eng
Number of pages: 7
Belongs to series: Journal of Medical Virology
ISSN: 0146-6615
DOI: https://doi.org/10.1002/jmv.25390
URI: http://hdl.handle.net/10138/313503
Abstract: Seoul virus (SEOV) is the etiologic agent of hemorrhagic fever with renal syndrome. It is carried by brown rats (Rattus norvegicus), a commensal rodent that closely cohabitates with humans in urban environments. SEOV has a worldwide distribution, and in Europe, it has been found in rats in UK, France, Sweden, and Belgium, and human cases of SEOV infection have been reported in Germany, UK, France, and Belgium. In the search of hantaviruses in brown rats from the Netherlands, we found both serological and genetic evidence for the presence of SEOV in the local wild rat population. To further decipher the relationship with other SEOV variants globally, the complete genome of SEOV in the Netherlands was recovered. SEOV sequences obtained from three positive rats (captured at close trapping locations at the same time) were found highly similar. Phylogenetic analyses demonstrated that two lineages of SEOV circulate in Europe. Strains from the Netherlands and UK, together with the Baxter strain from US, constitute one of these two, while the second includes strains from Europe and Asia. Our results support a hypothesis of diverse routes of SEOV spread into Europe. These findings, combined with other indications on the expansion of the spatial European range of SEOV, suggest an increased risk of this virus for the public health, highlighting the need for increased surveillance.
Subject: hantavirus
hemorrhagic fever with renal syndrome
phylogenetic analysis
Seoul virus
HEMORRHAGIC-FEVER
VIRUS-INFECTION
RENAL SYNDROME
OUTBREAK
HUMANS
WILD
EPIDEMIOLOGY
EVOLUTION
FRANCE
HOSTS
1183 Plant biology, microbiology, virology
3111 Biomedicine
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: publishedVersion


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