Anticholinergic drug use and its association with self-reported symptoms among older persons with and without diabetes

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dc.contributor.author Inkeri, Niina-Mari
dc.contributor.author Karjalainen, Merja
dc.contributor.author Haanpaa, Maija
dc.contributor.author Kautiainen, Hannu
dc.contributor.author Saltevo, Juha
dc.contributor.author Mantyselka, Pekka
dc.contributor.author Tiihonen, Miia
dc.date.accessioned 2020-03-21T23:24:39Z
dc.date.available 2021-12-17T22:45:30Z
dc.date.issued 2019-04
dc.identifier.citation Inkeri , N-M , Karjalainen , M , Haanpaa , M , Kautiainen , H , Saltevo , J , Mantyselka , P & Tiihonen , M 2019 , ' Anticholinergic drug use and its association with self-reported symptoms among older persons with and without diabetes ' , Journal of Clinical Pharmacy and Therapeutics , vol. 44 , no. 2 , pp. 229-235 . https://doi.org/10.1111/jcpt.12772
dc.identifier.other PURE: 123450535
dc.identifier.other PURE UUID: c831c3d9-19de-491d-bc65-94b304bdffb4
dc.identifier.other WOS: 000460316100012
dc.identifier.other Scopus: 85054852829
dc.identifier.uri http://hdl.handle.net/10138/313506
dc.description.abstract What is known and objective Anticholinergic drug use has been associated with a risk of central and peripheral adverse effects. There is a lack of information on anticholinergic drug use in persons with diabetes. The aim of this study is to investigate anticholinergic drug use and the association between anticholinergic drug use and self-reported symptoms in older community-dwelling persons with and without diabetes. Methods The basic population was comprised of Finnish community-dwelling primary care patients aged 65 and older. Persons with diabetes were identified according to the ICD-10 diagnostic codes from electronic patient records. Two controls adjusted by age and gender were selected for each person with diabetes. This cross-sectional study was based on electronic primary care patient records and a structured health questionnaire. The health questionnaire was returned by 430 (81.6%) persons with diabetes and 654 (73.5%) persons without diabetes. Data on prescribed drugs were obtained from the electronic patient records. Anticholinergic drug use was measured according to the Anticholinergic Risk Scale. The presence and strength of anticholinergic symptoms were asked in the health questionnaire. Results and discussion The prevalence of anticholinergic drug use was 8.9% in the total study cohort. There were no significant differences in anticholinergic drug use between persons with and without diabetes. There was no consistent association between anticholinergic drug use and self-reported symptoms. What is new and conclusion There is no difference in anticholinergic drug use in older community-dwelling persons with and without diabetes. Anticholinergic drug use should be considered individually and monitored carefully. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Journal of Clinical Pharmacy and Therapeutics
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject anticholinergic burden
dc.subject anticholinergic drug use
dc.subject diabetes mellitus
dc.subject older people
dc.subject BRAIN-BARRIER PERMEABILITY
dc.subject ELDERLY-PEOPLE
dc.subject RISK SCALES
dc.subject BURDEN
dc.subject MEDICATIONS
dc.subject MORTALITY
dc.subject RESIDENTS
dc.subject OUTCOMES
dc.subject 317 Pharmacy
dc.subject 3142 Public health care science, environmental and occupational health
dc.title Anticholinergic drug use and its association with self-reported symptoms among older persons with and without diabetes en
dc.type Article
dc.contributor.organization Neurokirurgian yksikkö
dc.contributor.organization Department of Neurosciences
dc.contributor.organization Clinicum
dc.contributor.organization Department of General Practice and Primary Health Care
dc.contributor.organization HUS Neurocenter
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/jcpt.12772
dc.relation.issn 0269-4727
dc.rights.accesslevel openAccess
dc.type.version publishedVersion
dc.identifier.url https://rdcu.be/bsd2f

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