Ahonen , T J , Rinne , M , Grutschreiber , P , Mätlik , K , Airavaara , M , Schaarschmidt , D , Lang , H , Reiss , D , Xhaard , H , Gaveriaux-Ruff , C , Yli-Kauhaluoma , J & Moreira , V M 2018 , ' Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors ' , European Journal of Medicinal Chemistry , vol. 151 , pp. 495-507 . https://doi.org/10.1016/j.ejmech.2018.02.074
Title: | Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors |
Author: | Ahonen, Tiina J.; Rinne, Maiju; Grutschreiber, Peter; Mätlik, Kert; Airavaara, Mikko; Schaarschmidt, Dieter; Lang, Heinrich; Reiss, David; Xhaard, Henri; Gaveriaux-Ruff, Claire; Yli-Kauhaluoma, Jari; Moreira, Vania M. |
Contributor organization: | Pharmaceutical Design and Discovery group Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy Drug Research Program Institute of Biotechnology Helsinki Institute of Life Science HiLIFE Henri Xhaard / Principal Investigator Computational Adme Doctoral Programme in Chemistry and Molecular Sciences Doctoral Programme in Drug Research Jari Yli-Kauhaluoma / Principal Investigator |
Date: | 2018-05-10 |
Language: | eng |
Number of pages: | 13 |
Belongs to series: | European Journal of Medicinal Chemistry |
ISSN: | 0223-5234 |
DOI: | https://doi.org/10.1016/j.ejmech.2018.02.074 |
URI: | http://hdl.handle.net/10138/313633 |
Abstract: | Despite extensive years of research, the direct oxidation of the 7,8-double bond of opioids has so far received little attention and knowledge about the effects of this modification on activity at the different opioid receptors is scarce. We herein report that potassium permanganate supported on iron(II) sulfate heptahydrate can be used as a convenient oxidant in the one-step, heterogeneous conversion of Delta(7.8)-opioids to the corresponding 7 beta-hydroxy-8-ketones. Details of the reaction mechanism are given and the effects of the substituent at position 6 of several opioids on the reaction outcome is discussed. The opioid hydroxy ketones prepared are antagonists at the mu- and delta-opioid receptors. Docking simulations and detailed structure-activity analysis revealed that the presence of the 7 beta-hydroxy-8-ketone functionality in the prepared compounds can be used to gain activity towards the delta opioid receptor. The 7 beta-hydroxy-8-ketones prepared with this method can also be regarded as versatile intermediates for the synthesis of other opioids of interest. (C) 2018 Elsevier Masson SAS. All rights reserved. |
Subject: |
Morphine
Oxidation Supported permanganate Hydroxy ketone Antagonist Opioid receptor HETEROGENEOUS PERMANGANATE OXIDATIONS POTASSIUM-PERMANGANATE SUPPORTED PERMANGANATE BINDING-PROPERTIES ORGANIC-COMPOUNDS MORPHINE ANALOGS OXIDIZING-AGENT CODEINE ACTIVATION EFFICIENT 317 Pharmacy |
Peer reviewed: | Yes |
Rights: | cc_by_nc_nd |
Usage restriction: | openAccess |
Self-archived version: | acceptedVersion |
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