Heparin Binding Protein in Adult Heart Surgery

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Pesonen , E , Passov , A , Salminen , U-S , Ilmakunnas , M , Vento , A , Aittomäki , J , Andersson , S & Schramko , A 2019 , ' Heparin Binding Protein in Adult Heart Surgery ' , Annals of Thoracic Surgery , vol. 107 , no. 4 , pp. 1154-1159 . https://doi.org/10.1016/j.athoracsur.2018.10.007

Title: Heparin Binding Protein in Adult Heart Surgery
Author: Pesonen, Eero; Passov, Arie; Salminen, Ulla-Stina; Ilmakunnas, Minna; Vento, Antti; Aittomäki, Juha; Andersson, Sture; Schramko, Alexey
Contributor organization: Clinicum
Anestesiologian yksikkö
Department of Diagnostics and Therapeutics
University of Helsinki
HUS Perioperative, Intensive Care and Pain Medicine
Department of Surgery
III kirurgian klinikka
HUS Heart and Lung Center
HUS Children and Adolescents
Children's Hospital
Date: 2019-04
Language: eng
Number of pages: 6
Belongs to series: Annals of Thoracic Surgery
ISSN: 0003-4975
DOI: https://doi.org/10.1016/j.athoracsur.2018.10.007
URI: http://hdl.handle.net/10138/313634
Abstract: Background. Heparin binding protein (HBP) is released from neutrophilic secretory vesicles upon neutrophil adhesion on the endothelium. HBP mediates capillary hyperpermeability experimentally. In sepsis, HBP predicts organ dysfunction. Cardiopulmonary bypass induces neutrophil activation and hyperpermeability. We hypothesized that in cardiopulmonary bypass, HBP is released in the reperfused coronary circulation concomitantly with neutrophil adhesion. Methods. In 30 patients undergoing aortic valve replacement, concomitant blood samples were drawn from the coronary sinus and arterial line before aortic cross-clamping and 5 minutes after reperfusion to calculate transcoronary differences. Plasma HBP concentrations, neutrophil markers lactoferrin and myeloperoxidase, myocardial injury marker heart-type fatty acid binding protein, and leukocyte differential counts were measured. Results. Arterial HBP was 4.1 ng/mL (interquartile range [IQR], 3.6 to 5.3 ng/mL) preoperatively and 150.0 ng/mL (IQR, 108.2 to 188.6 ng/mL) after aortic declamping. HBP increased 39-fold, lactoferrin 16-fold, and myeloperoxidase fourfold during cardiopulmonary bypass. Before cardiopulmonary bypass, there were marginal transcoronary differences in HBP (1.4 ng/mL; IQR, -0.4 to 3.6 ng/mL; p = 0.001) and heart-type fatty acid binding protein (0.4 ng/mL; IQR, -0.04 to 3.5 ng/mL; p = 0.001) but not in the other indicators. During reperfusion, transcoronary HBP release (6.4 ng/mL; IQR, 1.8 to 13.7; ng/mL; p <0.001) was observed concomitantly with transcoronary neutrophil sequestration (-0.14 3 109/L; IQR, -0.28 to 0.01 3 109/L; p = 0.001) and transcoronary heart-type fatty acid binding protein release (6.9 ng/mL; IQR, 3.0 to 25.8 ng/mL; p <0.001). There were no transcoronary differences in lactoferrin or myeloperoxidase during reperfusion. Conclusions. Cardiopulmonary bypass results in substantial increase in circulating HBP. HBP is also released from the reperfused coronary circulation concomitantly with coronary neutrophil adhesion and myocardial injury. HBP may be one candidate for a humoral factor mediating capillary leak in cardiopulmonary bypass. (C) 2019 by The Society of Thoracic Surgeons
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion

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