Cumulative Risk of End-Stage Renal Disease Among Patients With Type 2 Diabetes : A Nationwide Inception Cohort Study

Show full item record



Permalink

http://hdl.handle.net/10138/313693

Citation

Finne , P , Groop , P-H , Arffman , M , Kervinen , M , Helve , J , Gronhagen-Riska , C & Sund , R 2019 , ' Cumulative Risk of End-Stage Renal Disease Among Patients With Type 2 Diabetes : A Nationwide Inception Cohort Study ' , Diabetes Care , vol. 42 , no. 4 , pp. 539-544 . https://doi.org/10.2337/dc18-1485

Title: Cumulative Risk of End-Stage Renal Disease Among Patients With Type 2 Diabetes : A Nationwide Inception Cohort Study
Author: Finne, Patrik; Groop, Per-Henrik; Arffman, Martti; Kervinen, Marjo; Helve, Jaakko; Gronhagen-Riska, Carola; Sund, Reijo
Contributor: University of Helsinki, Nefrologian yksikkö
University of Helsinki, Department of Medicine
University of Helsinki, Department of Medicine
University of Helsinki, Department of Social Research (2010-2017)
Date: 2019-04
Language: eng
Number of pages: 6
Belongs to series: Diabetes Care
ISSN: 0149-5992
URI: http://hdl.handle.net/10138/313693
Abstract: OBJECTIVE To estimate long-term cumulative risk of end-stage renal disease (ESRD) after diagnosis of type 2 diabetes. RESEARCH DESIGN AND METHODS This nationwide population-based inception cohort study included 421,429 patients with type 2 diabetes diagnosed in 1990-2011; patients were followed until the end of 2013. Data linkage between several national health care registers in Finland, covering 100% of the population, enabled the inclusion of almost all inhabitants who started taking diabetes medication or were hospitalized for diabetes. Cumulative risk of ESRD and hazard ratios [HR] for ESRD and death were estimated according to age, sex, and time period of diabetes diagnosis. RESULTS Among 421,429 patients with type 2 diabetes, 1,516 developed ESRD and 150,524 died during 3,458,797 patient-years of follow-up. Cumulative risk of ESRD was 0.29% at 10 years and 0.74% at 20 years from diagnosis of diabetes. Risk was higher among men than among women (HR 1.93 [95% CI 1.72-2.16]), decreased with older age at diagnosis (HR 0.70 [95% CI 0.60-0.81] for age 60-69 vs. 40-49 years), and was lower for those diagnosed in 2000-2011 than in 1990-1994 (HR 0.72 [95% CI 0.63-0.81]). Patients diagnosed with diabetes in 2000-2011 had lower risk of death during follow-up than those diagnosed in 1990-1994 (HR 0.64 [95% CI 0.63-0.65]). CONCLUSIONS Cumulative risk of ESRD is minimal among patients with type 2 diabetes compared with their risk of death. Patients diagnosed with diabetes at an older age have a lower risk of ESRD due to higher competing mortality.
Subject: MORTALITY
POPULATION
MELLITUS
ONSET
MEN
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Cumulative_Risk_of_End_Stage.pdf 665.7Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record