Hyperthyroidism as a late effect in childhood cancer survivors-an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study

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dc.contributor University of Helsinki, Children's Hospital en
dc.contributor.author ALICCS Study Grp
dc.contributor.author Clausen, Camilla T.
dc.contributor.author Hasle, Henrik
dc.contributor.author Holmqvist, Anna S.
dc.contributor.author Madanat-Harjuoja, Laura
dc.contributor.author Tryggvadottir, Laufey
dc.contributor.author Wesenberg, Finn
dc.contributor.author Bautz, Andrea
dc.contributor.author Winther, Jeanette F.
dc.contributor.author Licht, Sofie de Fine
dc.date.accessioned 2020-03-31T01:55:53Z
dc.date.available 2021-01-18T03:45:37Z
dc.date.issued 2019-02-01
dc.identifier.citation ALICCS Study Grp , Clausen , C T , Hasle , H , Holmqvist , A S , Madanat-Harjuoja , L , Tryggvadottir , L , Wesenberg , F , Bautz , A , Winther , J F & Licht , S D F 2019 , ' Hyperthyroidism as a late effect in childhood cancer survivors-an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study ' , Acta Oncologica , vol. 58 , no. 2 , pp. 227-231 . https://doi.org/10.1080/0284186X.2018.1535187 en
dc.identifier.issn 0284-186X
dc.identifier.other PURE: 123500225
dc.identifier.other PURE UUID: 3b544f3b-e7bb-4891-8aaf-32c6dc929991
dc.identifier.other WOS: 000459608000014
dc.identifier.other Scopus: 85059102831
dc.identifier.uri http://hdl.handle.net/10138/313762
dc.description.abstract Background: Hyperthyroidism is a rare disorder which may negatively affect health and quality of life. Its occurrence in childhood cancer survivors has not previously been investigated in detail. Material and methods: In the hospital registers of the five Nordic countries, 32,944 childhood cancer survivors and 212,675 population comparisons were followed for the diagnosis of hyperthyroidism. Hospitalisation rates, standardised hospitalisation rate ratios and absolute excess risks were calculated with 95% confidence intervals (CI). Results: Hyperthyroidism was diagnosed in 131 childhood cancer survivors, yielding an overall relative risk of 1.6 (95% CI: 1.3-1.9) compared with population comparisons. The risk was greatest 1-5 years after the diagnosis of cancer and in survivors of thyroid cancers, neuroblastomas, acute lymphoblastic leukaemia and Hodgkin lymphoma. Sixty-seven percent of survivors with hyperthyroidism had tumours located in the head, neck or upper body and half of survivors with hyperthyroidism were irradiated with 77% of them in the head and neck area. Conclusion: Childhood cancer survivors are at an increased risk of hyperthyroidism, potentially resulting in non-endocrine morbidity. en
dc.format.extent 5
dc.language.iso eng
dc.relation.ispartof Acta Oncologica
dc.rights en
dc.subject ENDOCRINE COMPLICATIONS en
dc.subject THYROID-FUNCTION en
dc.subject BRAIN-TUMORS en
dc.subject ABNORMALITIES en
dc.subject 3122 Cancers en
dc.title Hyperthyroidism as a late effect in childhood cancer survivors-an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1080/0284186X.2018.1535187
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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