Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults

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http://hdl.handle.net/10138/313763

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Heikkinen , N , Kärkkäinen , O , Laukkanen , E , Kekkonen , V , Kaarre , O , Kivimäki , P , Könönen , M , Velagapudi , V , Nandania , J , Lehto , S M , Niskanen , E , Vanninen , R & Tolmunen , T 2019 , ' Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults ' , Alcohol (New York) , vol. 75 , pp. 89-97 . https://doi.org/10.1016/j.alcohol.2018.05.010

Title: Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults
Author: Heikkinen, Noora; Kärkkäinen, Olli; Laukkanen, Eila; Kekkonen, Virve; Kaarre, Outi; Kivimäki, Petri; Könönen, Mervi; Velagapudi, Vidya; Nandania, Jatin; Lehto, Soili M.; Niskanen, Eini; Vanninen, Ritva; Tolmunen, Tommi
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Department of Psychology and Logopedics
Date: 2019-03
Language: eng
Number of pages: 9
Belongs to series: Alcohol (New York)
ISSN: 0741-8329
URI: http://hdl.handle.net/10138/313763
Abstract: Our aim was to analyze metabolite profile changes in serum associated with moderate-to-heavy consumption of alcohol in young adults and to evaluate whether these changes are connected to reduced brain gray matter volumes. These study population consisted of young adults with a 10-year history of moderate-to-heavy alcohol consumption (n = 35) and light-drinking controls (n = 27). We used the targeted liquid chromatography mass spectrometry method to measure concentrations of metabolites in serum, and 3.0 T magnetic resonance imaging to assess brain gray matter volumes. Alterations in amino acid and energy metabolism were observed in the moderate-to-heavy drinking young adults when compared to the controls. After correction for multiple testing, the group of moderate-to-heavy drinking young adults had increased serum concentrations of 1-methylhistamine (p = 0.001, d = 0.82) when compared to the controls. Furthermore, concentrations of 1-methylhistamine (r = 0.48, p = 0.004) and creatine (r = 0.52, p = 0.001) were negatively correlated with the brain gray matter volumes in the females. Overall, our results show association between moderate-to-heavy use of alcohol and altered metabolite profile in young adults as well as suggesting that some of these changes could be associated with the reduced brain gray matter volume. (C) 2018 Elsevier Inc. All rights reserved.
Subject: Adolescence
Alcohol
Brain
Morphometry
MRI
ALCOHOL-USE
SUBSTANCE USE
HISTAMINE
CONSUMPTION
CREATINE
METHYLHISTAMINE
KINETICS
NUCLEUS
HEALTH
CORTEX
317 Pharmacy
3111 Biomedicine
3142 Public health care science, environmental and occupational health
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