OBEDIS Core Variables Project : European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions

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Alligier , M , Barres , R , Blaak , E E , Boirie , Y , Bouwman , J , Brunault , P , Campbell , K , Clement , K , Farooqi , I S , Farpour-Lambert , N J , Fruhbeck , G , Goossens , G H , Hager , J , Halford , J C G , Hauner , H , Jacobi , D , Julia , C , Langin , D , Natali , A , Neovius , M , Oppert , J M , Pagotto , U , Palmeira , A L , Roche , H , Ryden , M , Scheen , A J , Simon , C , Sorensen , T I A , Tappy , L , Yki-Järvinen , H , Ziegler , O & Laville , M 2020 , ' OBEDIS Core Variables Project : European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions ' , Obesity facts , vol. 13 , no. 1 , pp. 1-28 . https://doi.org/10.1159/000505342

Titel: OBEDIS Core Variables Project : European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions
Författare: Alligier, Maud; Barres, Romain; Blaak, Ellen E.; Boirie, Yves; Bouwman, Jildau; Brunault, Paul; Campbell, Kristina; Clement, Karine; Farooqi, I. Sadaf; Farpour-Lambert, Nathalie J.; Fruhbeck, Gema; Goossens, Gijs H.; Hager, Jorg; Halford, Jason C. G.; Hauner, Hans; Jacobi, David; Julia, Chantal; Langin, Dominique; Natali, Andrea; Neovius, Martin; Oppert, Jean Michel; Pagotto, Uberto; Palmeira, Antonio L.; Roche, Helen; Ryden, Mikael; Scheen, Andre J.; Simon, Chantal; Sorensen, Thorkild I. A.; Tappy, Luc; Yki-Järvinen, Hannele; Ziegler, Olivier; Laville, Martine
Upphovmannens organisation: Department of Medicine
HUS Internal Medicine and Rehabilitation
University of Helsinki
Datum: 2020-02
Språk: eng
Sidantal: 28
Tillhör serie: Obesity facts
ISSN: 1662-4025
DOI: https://doi.org/10.1159/000505342
Permanenta länken (URI): http://hdl.handle.net/10138/313769
Abstrakt: Heterogeneity of interindividual and intraindividual responses to interventions is often observed in randomized, controlled trials for obesity. To address the global epidemic of obesity and move toward more personalized treatment regimens, the global research community must come together to identify factors that may drive these heterogeneous responses to interventions. This project, called OBEDIS (OBEsity Diverse Interventions Sharing - focusing on dietary and other interventions), provides a set of European guidelines for a minimal set of variables to include in future clinical trials on obesity, regardless of the specific endpoints. Broad adoption of these guidelines will enable researchers to harmonize and merge data from multiple intervention studies, allowing stratification of patients according to precise phenotyping criteria which are measured using standardized methods. In this way, studies across Europe may be pooled for better prediction of individuals' responses to an intervention for obesity - ultimately leading to better patient care and improved obesity outcomes.
Subject: Obesity
Interventions
Variables
Precision medicine
Stratification
CORONARY-HEART-DISEASE
QUALITY-OF-LIFE
OBSTRUCTIVE SLEEP-APNEA
C-REACTIVE PROTEIN
BODY-MASS INDEX
GASTRIC BYPASS-SURGERY
WEIGHT-LOSS
PHYSICAL-ACTIVITY
METABOLIC SYNDROME
CARDIOVASCULAR-DISEASE
3121 General medicine, internal medicine and other clinical medicine
Referentgranskad: Ja
Licens: cc_by_nc_nd
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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