Tracking of Serum DHEAS Concentrations from Age 1 to 6 Years : A Prospective Cohort Study

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http://hdl.handle.net/10138/313772

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Liimatta , J , Jääskeläinen , J , Karvonen , A M , Remes , S , Voutilainen , R & Pekkanen , J 2020 , ' Tracking of Serum DHEAS Concentrations from Age 1 to 6 Years : A Prospective Cohort Study ' , Journal of the Endocrine Society , vol. 4 , no. 2 , 012 . https://doi.org/10.1210/jendso/bvaa012

Title: Tracking of Serum DHEAS Concentrations from Age 1 to 6 Years : A Prospective Cohort Study
Author: Liimatta, Jani; Jääskeläinen, Jarmo; Karvonen, Anne M.; Remes, Sami; Voutilainen, Raimo; Pekkanen, Juha
Contributor: University of Helsinki, Department of Public Health
Date: 2020-02
Language: eng
Number of pages: 11
Belongs to series: Journal of the Endocrine Society
ISSN: 2472-1972
URI: http://hdl.handle.net/10138/313772
Abstract: Context: Adrenarche is a gradual process, but its programming is unknown. Objective: The objective of this article is to examine the trajectory of dehydroepiandrosterone sulfate (DHEAS) from age 1 to 6 years and the associations of early growth with DHEAS concentration by age 6 years. Design and participants: Longitudinal data from a population sample of 78 children (43 girls) with serum samples for DHEAS and insulin-like growth factor 1 (IGF-1) measurements available at ages 1 and 6 years. Main outcome measure: Serum DHEAS concentration at age 6 years. Results: DHEAS concentration at age 1 year correlated with DHEAS concentration at age 6 years (r = 0.594, P <.001). DHEAS levels at age 6 years increased with tertiles of DHEAS at age 1 year (medians (mu g/dL); 4.2, 14.4, 22.6; P <.001) and with those of greater increase in length by age 1 year (6.0, 11.7, 16.4; P = .047), and decreased with Wailes of birth length (17.7, 13.3, 7.1; P = .042). In a regression model including birth size, biochemical covariates at age 1 year, and growth measures by age 6 years, higher DHEAS concentration at age 1 year was an independent determinant of falling into the highest DHEAS tertile at age 6 years. Conclusions: Higher serum DHEAS concentrations already at age 1 year are associated with those at age 6 years. Also, shorter birth length and rapid catch-up growth in length by age 1 year are associated with higher DHEAS concentrations at age 6 years. These results corroborate the early origin of adrenarche and strongly suggest that part of adrenarchal programming already takes place by the end of infancy. (C) Endocrine Society 2020.
Subject: adrenarche
birth size
growth
dehydroepiandrosterone sulfate
insulin-like growth factor 1
GROWTH-FACTOR-I
IGF-I
DEHYDROEPIANDROSTERONE-SULFATE
INSULIN SENSITIVITY
PREMATURE ADRENARCHE
BODY-COMPOSITION
PUBERTAL CHANGES
GESTATIONAL-AGE
HISPANIC GIRLS
CHILDREN
3142 Public health care science, environmental and occupational health
3121 General medicine, internal medicine and other clinical medicine
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