A comparative genomics study of 23 Aspergillus species from section Flavi

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http://hdl.handle.net/10138/313775

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Kjaerbolling , I , Vesth , T , Frisvad , J C , Nybo , J L , Theobald , S , Kildgaard , S , Petersen , T I , Kuo , A , Sato , A , Lyhne , E K , Kogle , M E , Wiebenga , A , Kun , R S , Lubbers , R J M , Makela , M R , Barry , K , Chovatia , M , Clum , A , Daum , C , Haridas , S , He , G , LaButti , K , Lipzen , A , Mondo , S , Pangilinan , J , Riley , R , Salamov , A , Simmons , B A , Magnuson , J K , Henrissat , B , Mortensen , U H , Larsen , T O , de Vries , R P , Grigoriev , I V , Machida , M , Baker , S E & Andersen , M R 2020 , ' A comparative genomics study of 23 Aspergillus species from section Flavi ' , Nature Communications , vol. 11 , no. 1 , 1106 . https://doi.org/10.1038/s41467-019-14051-y

Title: A comparative genomics study of 23 Aspergillus species from section Flavi
Author: Kjaerbolling, Inge; Vesth, Tammi; Frisvad, Jens C.; Nybo, Jane L.; Theobald, Sebastian; Kildgaard, Sara; Petersen, Thomas Isbrandt; Kuo, Alan; Sato, Atsushi; Lyhne, Ellen K.; Kogle, Martin E.; Wiebenga, Ad; Kun, Roland S.; Lubbers, Ronnie J. M.; Makela, Miia R.; Barry, Kerrie; Chovatia, Mansi; Clum, Alicia; Daum, Chris; Haridas, Sajeet; He, Guifen; LaButti, Kurt; Lipzen, Anna; Mondo, Stephen; Pangilinan, Jasmyn; Riley, Robert; Salamov, Asaf; Simmons, Blake A.; Magnuson, Jon K.; Henrissat, Bernard; Mortensen, Uffe H.; Larsen, Thomas O.; de Vries, Ronald P.; Grigoriev, Igor V.; Machida, Masayuki; Baker, Scott E.; Andersen, Mikael R.
Contributor: University of Helsinki, Department of Microbiology
Date: 2020-02-27
Language: eng
Number of pages: 12
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/313775
Abstract: Section Flavi encompasses both harmful and beneficial Aspergillus species, such as Aspergillus oryzae, used in food fermentation and enzyme production, and Aspergillus flavus, food spoiler and mycotoxin producer. Here, we sequence 19 genomes spanning section Flavi and compare 31 fungal genomes including 23 Flavi species. We reassess their phylogenetic relationships and show that the closest relative of A. oryzae is not A. flavus, but A. minisclerotigenes or A. aflatoxiformans and identify high genome diversity, especially in sub-telomeric regions. We predict abundant CAZymes (598 per species) and prolific secondary metabolite gene clusters (73 per species) in section Flavi. However, the observed phenotypes (growth characteristics, polysaccharide degradation) do not necessarily correlate with inferences made from the predicted CAZyme content. Our work, including genomic analyses, phenotypic assays, and identification of secondary metabolites, highlights the genetic and metabolic diversity within section Flavi.
Subject: METABOLITE GENE CLUSTERS
NIGER ATCC 1015
BIOSYNTHETIC-PATHWAY
HUMAN PATHOGEN
SEQUENCE
TAMARII
SOJAE
PURIFICATION
PARASITICUS
FUMIGATUS
11831 Plant biology
1182 Biochemistry, cell and molecular biology
1184 Genetics, developmental biology, physiology
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