Autophagy : supporting cellular and organismal homeostasis by self-eating

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http://hdl.handle.net/10138/313894

Lähdeviite

Eskelinen , E-L 2019 , ' Autophagy : supporting cellular and organismal homeostasis by self-eating ' , International Journal of Biochemistry & Cell Biology , vol. 111 , pp. 1-10 . https://doi.org/10.1016/j.biocel.2019.03.010

Julkaisun nimi: Autophagy : supporting cellular and organismal homeostasis by self-eating
Tekijä: Eskelinen, Eeva-Liisa
Muu tekijä: University of Helsinki, Molecular and Integrative Biosciences Research Programme
Päiväys: 2019-06
Kieli: eng
Sivumäärä: 10
Kuuluu julkaisusarjaan: International Journal of Biochemistry & Cell Biology
ISSN: 1357-2725
URI: http://hdl.handle.net/10138/313894
Tiivistelmä: Autophagy is a conserved catabolic process that delivers cytoplasmic components and organelles to lysosomes for degradation and recycling. This pathway serves to degrade nonfunctional organelles and aggregate-prone proteins, as well as to produce substrates for energy production and biosynthesis. Autophagy is especially important for the maintenance of stem cells, and for the survival and homeostasis of post-mitotic cells like neurons. Functional autophagy promotes longevity in several model organisms. Autophagy regulates immunity and inflammation at several levels and has both anti- and pro-tumorigenic roles in cancer. This review provides a concise overview of autophagy and its importance in cellular and organismal homeostasis, with emphasis on aging, stem cells, neuronal cells, immunity, inflammation, and cancer.
Avainsanat: 1182 Biochemistry, cell and molecular biology
autophagy
aging
stem cells
immunity
Inflammation
neurodegeneration
cancer
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