Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients : a position statement from an international expert group

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Mohty , M , Malard , F , Abecasis , M , Aerts , E , Alaskar , A S , Aljurf , M , Arat , M , Bader , P , Baron , F , Basak , G , Bazarbachi , A , Blaise , D , Ciceri , F , Corbacioglu , S , Dalle , J-H , Dignan , F , Fukuda , T , Huynh , A , Kuball , J , Lachance , S , Lazarus , H , Masszi , T , Michallet , M , Nagler , A , NiChonghaile , M , Okamoto , S , Pagliuca , A , Peters , C , Petersen , F B , Richardson , P G , Ruutu , T , Saber , W , Savani , B N , Soiffer , R , Styczynski , J , Wallhult , E , Yakoub-Agha , I , Duarte , R F & Carreras , E 2020 , ' Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients : a position statement from an international expert group ' , Bone Marrow Transplantation , vol. 55 , no. 3 , pp. 485-495 . https://doi.org/10.1038/s41409-019-0705-z

Title: Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients : a position statement from an international expert group
Author: Mohty, Mohamad; Malard, Florent; Abecasis, Manuel; Aerts, Erik; Alaskar, Ahmed S.; Aljurf, Mahmoud; Arat, Mutlu; Bader, Peter; Baron, Frederic; Basak, Grzegorz; Bazarbachi, Ali; Blaise, Didier; Ciceri, Fabio; Corbacioglu, Selim; Dalle, Jean-Hugues; Dignan, Fiona; Fukuda, Takahiro; Huynh, Anne; Kuball, Jurgen; Lachance, Silvy; Lazarus, Hillard; Masszi, Tamas; Michallet, Mauricette; Nagler, Arnon; NiChonghaile, Mairead; Okamoto, Shinichiro; Pagliuca, Antonio; Peters, Christina; Petersen, Finn B.; Richardson, Paul G.; Ruutu, Tapani; Saber, Wael; Savani, Bipin N.; Soiffer, Robert; Styczynski, Jan; Wallhult, Elisabeth; Yakoub-Agha, Ibrahim; Duarte, Rafael F.; Carreras, Enric
Contributor: University of Helsinki, HUS Comprehensive Cancer Center
Date: 2020-03
Language: eng
Number of pages: 11
Belongs to series: Bone Marrow Transplantation
ISSN: 0268-3369
URI: http://hdl.handle.net/10138/313991
Abstract: Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). While SOS/VOD may resolve within a few weeks in the majority of patients with mild-to-moderate disease, the most severe forms result in multiorgan dysfunction and are associated with a high mortality rate (>80%). Therefore, careful surveillance may allow early detection of SOS/VOD, particularly as the licensed available drug is proven to be effective and reduce mortality. The aim of this work is to propose an international consensus guideline for the treatment and prevention of SOS/VOD in adult patients, on behalf of an international expert group.
Subject: HEPATIC VENOOCCLUSIVE DISEASE
STEM-CELL TRANSPLANTATION
BONE-MARROW-TRANSPLANTATION
HAPLOIDENTICAL DONOR TRANSPLANTATION
REGIMEN-RELATED TOXICITIES
URSODEOXYCHOLIC ACID
PERIPHERAL-BLOOD
EUROPEAN-SOCIETY
RANDOMIZED-TRIAL
PD-1 BLOCKADE
3122 Cancers
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