Long‐term outcomes in juvenile idiopathic arthritis : Eighteen Years of Follow-Up in the Population-Based Nordic Juvenile Idiopathic Arthritis Cohort

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the Nordic Study Group of Pediatric Rheumatology (NoSPeR) , Glerup , M , Rypdal , V , Arnstad , E D , Ekelund , M , Peltoniemi , S , Aalto , K , Rygg , M , Toftedal , P , Nielsen , S , Fasth , A , Berntson , L , Nordal , E & Herlin , T 2020 , ' Long‐term outcomes in juvenile idiopathic arthritis : Eighteen Years of Follow-Up in the Population-Based Nordic Juvenile Idiopathic Arthritis Cohort ' , Arthritis Care & Research , vol. 72 , no. 4 , pp. 507-516 . https://doi.org/10.1002/acr.23853

Title: Long‐term outcomes in juvenile idiopathic arthritis : Eighteen Years of Follow-Up in the Population-Based Nordic Juvenile Idiopathic Arthritis Cohort
Author: the Nordic Study Group of Pediatric Rheumatology (NoSPeR); Glerup, Mia; Rypdal, Veronika; Arnstad, Ellen Dalen; Ekelund, Maria; Peltoniemi, Suvi; Aalto, Kristiina; Rygg, Marite; Toftedal, Peter; Nielsen, Susan; Fasth, Anders; Berntson, Lillemor; Nordal, Ellen; Herlin, Troels
Contributor organization: HUS Children and Adolescents
Children's Hospital
University of Helsinki
Date: 2020-04
Language: eng
Number of pages: 10
Belongs to series: Arthritis Care & Research
ISSN: 0893-7524
DOI: https://doi.org/10.1002/acr.23853
URI: http://hdl.handle.net/10138/314243
Abstract: Objective The present study was undertaken to assess the long-term course, remission rate, and disease burden in juvenile idiopathic arthritis (JIA) 18 years after disease onset in a population-based setting from the early biologic era. Methods A total of 510 consecutive cases of JIA with disease onset between 1997 and 2000 from defined geographic regions in Denmark, Norway, Sweden, and Finland were prospectively included in this 18-year cohort study. At the follow-up visit, patient-reported demographic and clinical data were collected. Results The study included 434 (85%) of the 510 eligible JIA participants. The mean +/- SD age was 24.0 +/- 4.4 years. The median juvenile arthritis disease activity score in 71 joints (JADAS-71) was 1.5 (interquartile range [IQR] 0-5), with the enthesitis-related arthritis (ERA) category of JIA having the highest median score (4.5 [IQR 1.5-8.5], P = 0.003). In this cohort, 46% of patients still had active disease, and 66 (15%) were treated with synthetic disease-modifying antirheumatic drugs and 84 (19%) with biologics. Inactive disease indicated by a JADAS-71 score of Conclusion A substantial proportion of the JIA cohort did not achieve CR despite new treatment options during the study period. The ERA category showed the worst outcomes, and in general there is still a high burden of disease in adulthood for JIA.
Subject: 3121 General medicine, internal medicine and other clinical medicine
OF-RHEUMATOLOGY RECOMMENDATIONS
DISEASE-ACTIVITY SCORE
SELECT CATEGORIES
REMISSION
CHILDREN
CRITERIA
VALIDATION
VALIDITY
SAFETY
OF-RHEUMATOLOGY RECOMMENDATIONS
DISEASE-ACTIVITY SCORE
SELECT CATEGORIES
REMISSION
CHILDREN
CRITERIA
VALIDATION
VALIDITY
SAFETY
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion


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