An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1)

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http://hdl.handle.net/10138/314409

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Cosgarea , I , Koelsch , B , Fischer , C , Griewank , K G , van den Berg , L , Kutritz , A , Schadendorf , D & Kindler-Röhrborn , A 2019 , ' An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1) ' , Journal of Investigative Dermatology , vol. 139 , no. 10 , pp. 2235-2238 . https://doi.org/10.1016/j.jid.2019.03.1154

Julkaisun nimi: An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1)
Tekijä: Cosgarea, Ioana; Koelsch, B.; Fischer, Christine; Griewank, Klaus G.; van den Berg, L.; Kutritz, Anja; Schadendorf, Dirk; Kindler-Röhrborn, Andrea
Muu tekijä: University of Helsinki, External Funding
Päiväys: 2019-10
Kieli: eng
Sivumäärä: 6
Kuuluu julkaisusarjaan: Journal of Investigative Dermatology
ISSN: 0022-202X
URI: http://hdl.handle.net/10138/314409
Tiivistelmä: Brief Summary Using inbred BN and LE/Stm rats susceptible and resistant, respectively, to chemically induced cutaneous cyst development we were able to further unveil the genetic architecture of inherited multiple cyst formation. N-methyl-N-nitrosourea-treated (BN x LE) F2 intercross rats proved to develop differential numbers of cutaneous cysts, demonstrating epidermal, trichilemmal and verrucous keratinization types. Male rats developed significantly more cysts per animal than females. QTL interval mapping yielded three loci on rat chromosomes 1, 8 and 11 (Ccd1, Ccd2, Ccd3) linked to cutaneous cyst formation. Ccd2 proved to be homologous to the human TRICY1 region which could further be narrowed down by genome comparison in both species. It contains 11 genes with evidence of expression in human keratinocytes.
Avainsanat: 3121 General medicine, internal medicine and other clinical medicine
HEREDITARY TRICHILEMMAL CYSTS
EPIDERMAL CYSTS
HEREDITARY TRICHILEMMAL CYSTS
EPIDERMAL CYSTS
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