An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1)

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dc.contributor University of Helsinki, External Funding en
dc.contributor.author Cosgarea, Ioana
dc.contributor.author Koelsch, B.
dc.contributor.author Fischer, Christine
dc.contributor.author Griewank, Klaus G.
dc.contributor.author van den Berg, L.
dc.contributor.author Kutritz, Anja
dc.contributor.author Schadendorf, Dirk
dc.contributor.author Kindler-Röhrborn, Andrea
dc.date.accessioned 2020-04-27T01:17:31Z
dc.date.available 2021-07-09T12:45:23Z
dc.date.issued 2019-10
dc.identifier.citation Cosgarea , I , Koelsch , B , Fischer , C , Griewank , K G , van den Berg , L , Kutritz , A , Schadendorf , D & Kindler-Röhrborn , A 2019 , ' An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1) ' , Journal of Investigative Dermatology , vol. 139 , no. 10 , pp. 2235-2238 . https://doi.org/10.1016/j.jid.2019.03.1154 en
dc.identifier.issn 0022-202X
dc.identifier.other PURE: 124490512
dc.identifier.other PURE UUID: 6f9deac2-98c3-4253-a5ba-8203dd68b14c
dc.identifier.other RIS: urn:547C9A840B1B902911836CE7A3FE594A
dc.identifier.other WOS: 000486620700036
dc.identifier.uri http://hdl.handle.net/10138/314409
dc.description.abstract Brief Summary Using inbred BN and LE/Stm rats susceptible and resistant, respectively, to chemically induced cutaneous cyst development we were able to further unveil the genetic architecture of inherited multiple cyst formation. N-methyl-N-nitrosourea-treated (BN x LE) F2 intercross rats proved to develop differential numbers of cutaneous cysts, demonstrating epidermal, trichilemmal and verrucous keratinization types. Male rats developed significantly more cysts per animal than females. QTL interval mapping yielded three loci on rat chromosomes 1, 8 and 11 (Ccd1, Ccd2, Ccd3) linked to cutaneous cyst formation. Ccd2 proved to be homologous to the human TRICY1 region which could further be narrowed down by genome comparison in both species. It contains 11 genes with evidence of expression in human keratinocytes. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof Journal of Investigative Dermatology
dc.rights en
dc.subject 3121 General medicine, internal medicine and other clinical medicine en
dc.subject HEREDITARY TRICHILEMMAL CYSTS en
dc.subject EPIDERMAL CYSTS en
dc.subject HEREDITARY TRICHILEMMAL CYSTS en
dc.subject EPIDERMAL CYSTS en
dc.title An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1) en
dc.type Letter
dc.identifier.doi https://doi.org/10.1016/j.jid.2019.03.1154
dc.type.uri info:eu-repo/semantics/other
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