Levels of glial cell line-derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in parkinson's disease

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Virachit , S , Mathews , K J , Cottam , V , Werry , E , Galli , E , Rappou , E , Lindholm , P , Saarma , M , Halliday , G M , Weickert , C S & Double , K L 2019 , ' Levels of glial cell line-derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in parkinson's disease ' , Brain Pathology , vol. 29 , no. 6 , pp. 813-825 . https://doi.org/10.1111/bpa.12730

Title: Levels of glial cell line-derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in parkinson's disease
Author: Virachit, Sophie; Mathews, Kathryn J.; Cottam, Veronica; Werry, Eryn; Galli, Emilia; Rappou, Elisabeth; Lindholm, Pӓivi; Saarma, Mart; Halliday, Glenda M.; Weickert, Cynthia Shannon; Double, Kay L.
Contributor organization: Institute of Biotechnology
University of Helsinki
Helsinki University Hospital Area
Diabetes and Obesity Research Program
Mart Saarma / Principal Investigator
Date: 2019-11
Language: eng
Number of pages: 13
Belongs to series: Brain Pathology
ISSN: 1015-6305
DOI: https://doi.org/10.1111/bpa.12730
URI: http://hdl.handle.net/10138/314480
Abstract: Growth factors can facilitate hippocampus-based learning and memory and are potential targets for treatment of cognitive dysfunction via their neuroprotective and neurorestorative effects. Dementia is common in Parkinson's disease (PD), but treatment options are limited. We aimed to determine if levels of growth factors are altered in the hippocampus of patients with PD, and if such alterations are associated with PD pathology. Enzyme-linked immunosorbent assays were used to quantify seven growth factors in fresh frozen hippocampus from 10 PD and nine age-matched control brains. Western blotting and immunohistochemistry were used to explore cellular and inflammatory changes that may be associated with growth factor alterations. In the PD hippocampus, protein levels of glial cell line-derived neurotrophic factor were significantly decreased, despite no evidence of neuronal loss. In contrast, protein levels of fibroblast growth factor 2 and cerebral dopamine neurotrophic factor were significantly increased in PD compared to controls. Levels of the growth factors epidermal growth factor, heparin-binding epidermal growth factor, brain-derived neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor did not differ between groups. Our data demonstrate changes in specific growth factors in the hippocampus of the PD brain, which potentially represent targets for modification to help attenuate cognitive decline in PD. These data also suggest that multiple growth factors and direction of change needs to be considered when approaching growth factors as a potential treatment for cognitive decline.
Subject: 3112 Neurosciences
Parkinson's disease
hippocampus
fibroblast growth factor 2
glial cell line-derived neurotrophic factor
cerebral dopamine neurotrophic factor
ALZHEIMERS-DISEASE
CDNF/MANF FAMILY
ENDOPLASMIC-RETICULUM STRESS
ALPHA-SYNUCLEIN
MILD COGNITIVE IMPAIRMENT
SUBSTANTIA-NIGRA
RAT MODEL
LOCUS-COERULEUS
LONG-TERM POTENTIATION
QUALITY-OF-LIFE
3124 Neurology and psychiatry
3111 Biomedicine
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion


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