Time course of signaling profiles of blood leukocytes in acute pancreatitis and sepsis

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Turunen , A , Kuuliala , A , Penttilä , A , Kaukonen , K-M , Mustonen , H , Pettilä , V , Puolakkainen , P , Kylänpää , L & Kuuliala , K 2020 , ' Time course of signaling profiles of blood leukocytes in acute pancreatitis and sepsis ' , Scandinavian Journal of Clinical & Laboratory Investigation , vol. 80 , no. 2 , pp. 114-123 . https://doi.org/10.1080/00365513.2019.1700548

Title: Time course of signaling profiles of blood leukocytes in acute pancreatitis and sepsis
Author: Turunen, Antti; Kuuliala, Antti; Penttilä, Anne; Kaukonen, Kirsi-Maija; Mustonen, Harri; Pettilä, Ville; Puolakkainen, Pauli; Kylänpää, Leena; Kuuliala, Krista
Contributor organization: HUS Abdominal Center
University of Helsinki
II kirurgian klinikka
Medicum
Department of Bacteriology and Immunology
HUSLAB
Clinicum
Department of Surgery
HUS Perioperative, Intensive Care and Pain Medicine
Department of Diagnostics and Therapeutics
Anestesiologian yksikkö
University Management
Pauli Puolakkainen / Principal Investigator
Teachers' Academy
Date: 2020-02-17
Language: eng
Number of pages: 10
Belongs to series: Scandinavian Journal of Clinical & Laboratory Investigation
ISSN: 0036-5513
DOI: https://doi.org/10.1080/00365513.2019.1700548
URI: http://hdl.handle.net/10138/314492
Abstract: Activation of intracellular signaling pathways in circulating leukocytes represents an early step in systemic immune-inflammatory response occurring e.g. in acute pancreatitis (AP) and sepsis. Previously, we found aberrations in the phosphorylation of leukocyte signaling proteins in patients with sepsis or AP (measured
Subject: Pancreatitis
sepsis
leukocytes
flow cytometry
signal transduction
NF-KAPPA-B
ORGAN FAILURE
INFLAMMATION
EXPRESSION
SEVERITY
MONOCYTE
IMMUNOSUPPRESSION
DEFINITIONS
MACROPHAGES
NEUTROPHILS
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion


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