Genetic Determinants of Glycated Hemoglobin in Type 1 Diabetes

Show simple item record DCCT EDIC Res Grp FinnDiane Study Grp Syreeni, Anna Sandholm, Niina Cao, Jingjing Toppila, Iiro Maahs, David M. Rewers, Marian J. Snell-Bergeon, Janet K. Costacou, Tina Orchard, Trevor J. Caramori, M. Luiza Mauer, Michael Klein, Barbara E. K. Klein, Ronald Valo, Erkka Parkkonen, Maija Forsblom, Carol Harjutsalo, Valma Paterson, Andrew D. Groop, Per-Henrik 2020-04-30T00:01:42Z 2021-12-17T22:45:49Z 2019-04-01
dc.identifier.citation DCCT EDIC Res Grp , FinnDiane Study Grp , Syreeni , A , Sandholm , N , Cao , J , Toppila , I , Maahs , D M , Rewers , M J , Snell-Bergeon , J K , Costacou , T , Orchard , T J , Caramori , M L , Mauer , M , Klein , B E K , Klein , R , Valo , E , Parkkonen , M , Forsblom , C , Harjutsalo , V , Paterson , A D & Groop , P-H 2019 , ' Genetic Determinants of Glycated Hemoglobin in Type 1 Diabetes ' , Diabetes , vol. 68 , no. 4 , pp. 858-867 .
dc.identifier.other PURE: 123848450
dc.identifier.other PURE UUID: 6fc996ac-9cab-4675-b931-00dd8c36fb78
dc.identifier.other WOS: 000462053100017
dc.identifier.other Scopus: 85063676378
dc.identifier.other ORCID: /0000-0003-4322-6942/work/56405803
dc.identifier.other ORCID: /0000-0003-0672-554X/work/66367076
dc.identifier.other ORCID: /0000-0003-1857-2560/work/83841743
dc.description.abstract Glycated hemoglobin (HbA(1c)) is an important measure of glycemia in diabetes. HbA(1c) is influenced by environmental and genetic factors both in people with and in people without diabetes. We performed a genome-wide association study (GWAS) for HbA(1c) in a Finnish type 1 diabetes (T1D) cohort, FinnDiane. Top results were examined for replication in T1D cohorts DCCT/EDIC, WESDR, CACTI, EDC, and RASS, and a meta-analysis was performed. Three SNPs in high linkage disequilibrium on chromosome 13 near relaxin family peptide receptor 2 (RXFP2) were associated with HbA(1c) in FinnDiane at genome-wide significance (P <5 x 10(-8)). The minor alleles of rs2085277 and rs1360072 were associated with higher HbA(1c) also in the meta-analysis with RASS (P <5 x 10(-8)), where these variants had minor allele frequencies 1%. Furthermore, these SNPs were associated with HbA(1c) in an East Asian population without diabetes (P 0.013). A weighted genetic risk score created from 55 HbA(1c)-associated variants from the literature was associated with HbA(1c) in FinnDiane but explained only a small amount of variation. Understanding the genetic basis of glycemic control and HbA(1c) may lead to better prevention of diabetes complications. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Diabetes
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject HBA(1C) LEVELS
dc.subject LOCI
dc.subject RELAXIN
dc.subject GLUCOSE
dc.subject ANNOTATION
dc.subject INSULIN
dc.subject FAMILY
dc.subject RISK
dc.subject A1C
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 3111 Biomedicine
dc.title Genetic Determinants of Glycated Hemoglobin in Type 1 Diabetes en
dc.type Article
dc.contributor.organization Nefrologian yksikkö
dc.contributor.organization Department of Medicine
dc.contributor.organization Clinicum
dc.contributor.organization University of Helsinki
dc.contributor.organization CAMM - Research Program for Clinical and Molecular Metabolism
dc.contributor.organization Faculty of Medicine
dc.contributor.organization Research Programs Unit
dc.contributor.organization Per Henrik Groop / Principal Investigator
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization HUS Internal Medicine and Rehabilitation
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0012-1797
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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