Airway hyperresponsiveness in young children with respiratory symptoms A five-year follow-up

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http://hdl.handle.net/10138/314613

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Kalliola , S , Malmberg , L P , Malmstrom , K , Pelkonen , A S & Mäkelä , M J 2019 , ' Airway hyperresponsiveness in young children with respiratory symptoms A five-year follow-up ' , Annals of Allergy, Asthma, & Immunology , vol. 122 , no. 5 , pp. 492-497 . https://doi.org/10.1016/j.anai.2019.02.025

Title: Airway hyperresponsiveness in young children with respiratory symptoms A five-year follow-up
Author: Kalliola, Satu; Malmberg, L. Pekka; Malmstrom, Kristiina; Pelkonen, Anna S.; Mäkelä, Mika J.
Contributor: University of Helsinki, HUS Children and Adolescents
University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, Department of Dermatology, Allergology and Venereology
Date: 2019-05
Language: eng
Number of pages: 6
Belongs to series: Annals of Allergy, Asthma, & Immunology
ISSN: 1081-1206
URI: http://hdl.handle.net/10138/314613
Abstract: Background: Recurrent wheezing in early life is transient in most children. The significance of airway hyper-responsiveness (AHR) in persistence of respiratory symptoms from infancy to early childhood is controversial. Objective: We evaluated whether AHR in wheezy infants predicts doctor-diagnosed asthma (DDA) or AHR at the age of 6 years. Methods: Sixty-one wheezy infants (age 6-24 months) were followed up to the median age of 6 years. Lung function and AHR with methacholine challenge test were assessed at infancy and 6 years. The exercise challenge test was performed at the age of 6 years. Atopy was assessed with skin prick tests. Results: At 6 years, 21 (34%) of the children had DDA. Children with DDA had higher logarithmic transformed dose-response slope (LOGDRS) to methacholine in infancy than children without DDA (0.047 vs 0.025; P = .033). Furthermore, AHR to methacholine in infancy and at 6 years were associated with each other (r = 0.324, P = .011). Children with exercise-induced bronchoconstriction (EIB) at 6 years were more reactive to methacholine in infancy than those without EIB (P = .019). Conclusion: Increased AHR in symptomatic infants was associated with increased AHR, DDA, and EIB at median the age of 6 years, suggesting early establishment of AHR. (C) 2019 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Subject: 1ST 6 YEARS
BRONCHIAL RESPONSIVENESS
LUNG-FUNCTION
WHEEZING PHENOTYPES
ASTHMA
INFANTS
METHACHOLINE
CHALLENGE
IMPEDANCE
EXERCISE
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
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