Airway hyperresponsiveness in young children with respiratory symptoms A five-year follow-up

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Kalliola , S , Malmberg , L P , Malmstrom , K , Pelkonen , A S & Mäkelä , M J 2019 , ' Airway hyperresponsiveness in young children with respiratory symptoms A five-year follow-up ' , Annals of Allergy, Asthma, & Immunology , vol. 122 , no. 5 , pp. 492-497 . https://doi.org/10.1016/j.anai.2019.02.025

Title: Airway hyperresponsiveness in young children with respiratory symptoms A five-year follow-up
Author: Kalliola, Satu; Malmberg, L. Pekka; Malmstrom, Kristiina; Pelkonen, Anna S.; Mäkelä, Mika J.
Contributor organization: HUS Children and Adolescents
Children's Hospital
Clinicum
Lohja Hospital Area
Department of Dermatology, Allergology and Venereology
HUS Inflammation Center
Date: 2019-05
Language: eng
Number of pages: 6
Belongs to series: Annals of Allergy, Asthma, & Immunology
ISSN: 1081-1206
DOI: https://doi.org/10.1016/j.anai.2019.02.025
URI: http://hdl.handle.net/10138/314613
Abstract: Background: Recurrent wheezing in early life is transient in most children. The significance of airway hyper-responsiveness (AHR) in persistence of respiratory symptoms from infancy to early childhood is controversial. Objective: We evaluated whether AHR in wheezy infants predicts doctor-diagnosed asthma (DDA) or AHR at the age of 6 years. Methods: Sixty-one wheezy infants (age 6-24 months) were followed up to the median age of 6 years. Lung function and AHR with methacholine challenge test were assessed at infancy and 6 years. The exercise challenge test was performed at the age of 6 years. Atopy was assessed with skin prick tests. Results: At 6 years, 21 (34%) of the children had DDA. Children with DDA had higher logarithmic transformed dose-response slope (LOGDRS) to methacholine in infancy than children without DDA (0.047 vs 0.025; P = .033). Furthermore, AHR to methacholine in infancy and at 6 years were associated with each other (r = 0.324, P = .011). Children with exercise-induced bronchoconstriction (EIB) at 6 years were more reactive to methacholine in infancy than those without EIB (P = .019). Conclusion: Increased AHR in symptomatic infants was associated with increased AHR, DDA, and EIB at median the age of 6 years, suggesting early establishment of AHR. (C) 2019 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Subject: 1ST 6 YEARS
BRONCHIAL RESPONSIVENESS
LUNG-FUNCTION
WHEEZING PHENOTYPES
ASTHMA
INFANTS
METHACHOLINE
CHALLENGE
IMPEDANCE
EXERCISE
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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