Development of atopic sensitization in Finnish and Estonian children : A latent class analysis in a multicenter cohort

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Diabimmune Study Grp , Schmidt , F , Hose , A J , Siljander , H , Knip , M & Ege , M J 2019 , ' Development of atopic sensitization in Finnish and Estonian children : A latent class analysis in a multicenter cohort ' , Journal of Allergy and Clinical Immunology , vol. 143 , no. 5 , pp. 1904-+ . https://doi.org/10.1016/j.jaci.2018.12.1014

Title: Development of atopic sensitization in Finnish and Estonian children : A latent class analysis in a multicenter cohort
Author: Diabimmune Study Grp; Schmidt, Felicitas; Hose, Alexander J.; Siljander, Heli; Knip, Mikael; Ege, Markus J.
Contributor: University of Helsinki, Children's Hospital
University of Helsinki, Children's Hospital
Date: 2019-05
Language: eng
Number of pages: 19
Belongs to series: Journal of Allergy and Clinical Immunology
ISSN: 0091-6749
URI: http://hdl.handle.net/10138/314621
Abstract: Background: The prevalence of atopy is associated with a Western lifestyle, as shown by studies comparing neighboring regions with different socioeconomic backgrounds. Atopy might reflect various conditions differing in their susceptibility to environmental factors. Objective: We sought to define phenotypes of atopic sensitization in early childhood and examine their association with allergic diseases and hereditary background in Finland and Estonia. Methods: The analysis included 1603 Finnish and 1657 Estonian children from the DIABIMMUNE multicenter young children cohort. Specific IgE levels were measured at age 3, 4, and 5 years, respectively, and categorized into 3 CAP classes. Latent class analysis was performed with the statistical software package poLCA in R software. Results: Both populations differed in terms of socioeconomic status and environmental determinants, such as pet ownership, farm-related exposure, time spent playing outdoors, and prevalence of allergic diseases (all P Conclusion: Despite profound differences in environmental exposures, there might exist genuine patterns of atopic sensitization. The distribution of these patterns might determine the contribution of atopic sensitization to disease onset.
Subject: Latent class analysis
unsupervised clustering
IgE
atopy
allergy
diabetes type 1 risk
wheezing
Finland
Estonia
severe atopy
BETA-CELL AUTOIMMUNITY
SERUM IGE LEVELS
ALLERGIC SENSITIZATION
ENVIRONMENTAL-FACTORS
INHALANT ALLERGENS
RUSSIAN KARELIA
ASTHMA
CHILDHOOD
DISEASE
ASSOCIATION
3121 General medicine, internal medicine and other clinical medicine
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