Second primary cancers in non-Hodgkin lymphoma: family history and survival

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Chattopadhyay , S , Zheng , G , Sud , A , Sundquist , K , Sundquist , J , Försti , A , Houlston , R , Hemminki , A & Hemminki , K 2020 , ' Second primary cancers in non-Hodgkin lymphoma: family history and survival ' , International Journal of Cancer , vol. 146 , no. 4 , pp. 970-976 .

Title: Second primary cancers in non-Hodgkin lymphoma: family history and survival
Author: Chattopadhyay, Subhayan; Zheng, Guoqiao; Sud, Amit; Sundquist, Kristina; Sundquist, Jan; Försti, Asta; Houlston, Richard; Hemminki, Akseli; Hemminki, Kari
Contributor organization: Department of Oncology
HUS Comprehensive Cancer Center
University of Helsinki
Faculty of Medicine
Date: 2020-02-15
Language: eng
Number of pages: 7
Belongs to series: International Journal of Cancer
ISSN: 0020-7136
Abstract: Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses and family history of cancer may be a risk factor for SPCs. Using the Swedish Family-Cancer Database on non-Hodgkin lymphoma (NHL), we assessed the influence of family history on risk of SPCs and of SPCs on survival. NHL patients were identified from the years 1958 to 2015 and generalized Poisson models were used to calculate relative risks (RRs) for SPCs and familial SPCs. Among 14,393 NHL patients, a total of 1,866 (13.0%) were diagnosed with SPC. Familial risk of nine particular cancers were associated with risks of these cancers as SPCs, with 2 to 5-fold increases in RRs. At the end of a 25-year follow-up period, the survival probability for persons with SPC was only 20% of that for patients without SPC; the hazard ratio for SPC was 1.59 (95% CI: 1.46 ? 1.72). Survival could be predicted by the prognostic groups based on first cancers and HRs increase systematically with worse prognosis yielding a trend of P = 4.6x10-5. SPCs had deleterious consequences for survival in NHL patients. Family history was associated with increasing numbers of SPCs. Prevention of SPCs and their early detection is an important target in the overall strategy to improve survival in NHL patients. Counseling for avoidance of risk factors and targeted screening based on family history are feasible steps in risk reduction. This article is protected by copyright. All rights reserved.
Subject: 3122 Cancers
second cancers
familial risk
prognostic grouping
EUROPE 1999-2007
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion

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