Polypharmacy-induced cognitive dysfunction and discontinuation of psychotropic medication : A neuropsychological case report

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Valtonen , J & Karrasch , M 2020 , ' Polypharmacy-induced cognitive dysfunction and discontinuation of psychotropic medication : A neuropsychological case report ' , Therapeutic advances in psychopharmacology , vol. 10 , no. January-December , 2045125320905734 . https://doi.org/10.1177/2045125320905734

Title: Polypharmacy-induced cognitive dysfunction and discontinuation of psychotropic medication : A neuropsychological case report
Author: Valtonen, Jussi; Karrasch, Mira
Contributor: University of Helsinki, Medicum
Date: 2020-04-28
Language: eng
Number of pages: 14
Belongs to series: Therapeutic advances in psychopharmacology
ISSN: 2045-1253
URI: http://hdl.handle.net/10138/314665
Abstract: Polypharmacy is common in patients with a diagnosis of bipolar disorder. Although polypharmacy is known to increase the risk of iatrogenic neurological conditions, the recovery of cognitive function after drug withdrawal has been rarely documented in psychiatric patients using standardized neuropsychological methods. We present a neuropsychological case report of patient SN, a 41-year-old woman who developed a socially and occupationally detrimental condition of cognitive dysfunction likely induced by long-term exposure to lithium and other psychiatric medications. To shed light on SN’s cognitive deficits and their recovery after drug withdrawal, neuropsychological assessments were conducted before, and approximately 2 years after, lithium and other psychiatric drugs were discontinued. Selective cognitive impairments were observed before drug discontinuation in visuomotor speed, visuoperceptual reasoning and delayed visual memory. Partial, but not complete, recovery of function was observed 2 years after drug withdrawal.
Subject: 6162 Cognitive science
515 Psychology
bipolar disorder
brain disorders
case report
cognitive impairment
lithium
polypharmacy
EUTHYMIC BIPOLAR PATIENTS
LITHIUM-CARBONATE
ANTIPSYCHOTIC POLYPHARMACY
PSYCHOMOTOR PERFORMANCE
TARDIVE-DYSKINESIA
NEUROTOXICITY
INTOXICATION
DISORDER
MEMORY
SCHIZOPHRENIA
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