Increased MHC Matching by C4 Gene Compatibility in Unrelated Donor Hematopoietic Stem Cell Transplantation

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dc.contributor.author Clancy, Jonna
dc.contributor.author Ritari, Jarmo
dc.contributor.author Lobier, Muriel
dc.contributor.author Niittyvuopio, Riitta
dc.contributor.author Salmenniemi, Urpu
dc.contributor.author Putkonen, Mervi
dc.contributor.author Itälä-Remes, Maija
dc.contributor.author Partanen, Jukka
dc.contributor.author Koskela, Satu
dc.date.accessioned 2020-05-07T02:10:27Z
dc.date.available 2021-12-18T03:45:59Z
dc.date.issued 2019-05
dc.identifier.citation Clancy , J , Ritari , J , Lobier , M , Niittyvuopio , R , Salmenniemi , U , Putkonen , M , Itälä-Remes , M , Partanen , J & Koskela , S 2019 , ' Increased MHC Matching by C4 Gene Compatibility in Unrelated Donor Hematopoietic Stem Cell Transplantation ' , Biology of Blood and Marrow Transplantation , vol. 25 , no. 5 , pp. 891-898 . https://doi.org/10.1016/j.bbmt.2018.12.759
dc.identifier.other PURE: 125801407
dc.identifier.other PURE UUID: ab21ecf2-ebf0-4914-b005-e6253dbaa838
dc.identifier.other WOS: 000469164700006
dc.identifier.uri http://hdl.handle.net/10138/314709
dc.description.abstract HLA matching is a prerequisite for successful allogeneic hematopoietic stem cell transplantation (HSCT) because it lowers the occurrence and severity of graft-versus-host disease (GVHD). However, matching a few alleles of the classic HLA genes only may not ensure matching of the entire MHC region. HLA haplotype matching has been reported to be beneficial in HSCT because of the variation relevant to GVHD risk in the non-HLA region. Because polymorphism in the MHC is highly population specific, we hypothesized that donors from the Finnish registry are more likely to be matched at a higher level for the Finnish patients than donors from other registries. In the present study we determined 25 single nucleotide polymorphisms (SNPs) of the complement component 4 (C4) gene in the gamma-block segment of MHC from 115 Finnish HSCT patients and their Finnish (n = 201) and non-Finnish (n = 280) donor candidates. Full matching of HLA alleles and C4 SNPs, independently or additively, occurred more likely in the Finnish-Finnish group as compared with the Finnish non-Finnish group (P <.003). This was most striking in cases with HLA haplotypes typical of the Finnish population. Patients with ancestral HLA haplotypes (AH) were more likely to find a full HLA and C4 matched donor, regardless of donor origin, as compared with patients without AH (P <.0001). Despite the clear differences at the population level, we could not find a statistical association between C4 matching and clinical outcome. The results suggest that screening C4 SNPs can be advantageous when an extended MHC matching or HLA haplotype matching in HSCT is required. This study also supports the need for small population-specific stem cell registries. (C) 2018 American Society for Blood and Marrow Transplantation. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Biology of Blood and Marrow Transplantation
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject HSCT
dc.subject MHC
dc.subject HLA haplotype
dc.subject Isolate population
dc.subject MAJOR HISTOCOMPATIBILITY COMPLEX
dc.subject HIGH-RESOLUTION HLA
dc.subject CONSERVED EXTENDED HAPLOTYPES
dc.subject LINKAGE-DISEQUILIBRIUM MAP
dc.subject GENOME-WIDE
dc.subject MEIOTIC RECOMBINATION
dc.subject GAMMA BLOCK
dc.subject POPULATION
dc.subject POLYMORPHISM
dc.subject FREQUENCIES
dc.subject 3111 Biomedicine
dc.title Increased MHC Matching by C4 Gene Compatibility in Unrelated Donor Hematopoietic Stem Cell Transplantation en
dc.type Article
dc.contributor.organization HUS Comprehensive Cancer Center
dc.contributor.organization Hematologian yksikkö
dc.contributor.organization Clinicum
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.bbmt.2018.12.759
dc.relation.issn 1083-8791
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion
dc.type.version publishedVersion

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