Chronic Alcohol Causes Alteration of Lipidome Profiling in Brain

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dc.contributor.author Wang, Liang
dc.contributor.author Li, Menglu
dc.contributor.author Bu, Qian
dc.contributor.author Li, Hongchun
dc.contributor.author Xu, Wei
dc.contributor.author Liu, Chunqi
dc.contributor.author Gu, Hui
dc.contributor.author Zhang, Jiamei
dc.contributor.author Wan, Xuemei
dc.contributor.author Zhao, Yinglan
dc.contributor.author Cen, Xiaobo
dc.date.accessioned 2020-05-11T01:55:27Z
dc.date.available 2021-12-17T22:45:49Z
dc.date.issued 2019-10-01
dc.identifier.citation Wang , L , Li , M , Bu , Q , Li , H , Xu , W , Liu , C , Gu , H , Zhang , J , Wan , X , Zhao , Y & Cen , X 2019 , ' Chronic Alcohol Causes Alteration of Lipidome Profiling in Brain ' , Toxicology Letters , vol. 313 , pp. 19-29 . https://doi.org/10.1016/j.toxlet.2019.05.010
dc.identifier.other PURE: 125029326
dc.identifier.other PURE UUID: 5bf0e771-5da7-4495-924c-491eabe5ead8
dc.identifier.other RIS: urn:ECB172E0C519C0AA48AC88C5A37BFD73
dc.identifier.other WOS: 000475915000003
dc.identifier.uri http://hdl.handle.net/10138/314746
dc.description.abstract Much efforts have been tried to clarify the molecular mechanism of alcohol-induced brain damage from the perspective of genome and protein; however, the effect of chronic alcohol exposure on global lipid profiling of brain is unclear. In the present study, by using Q-TOF/MS-based lipidomics approach, we investigated the comprehensive lipidome profiling of brain from the rats orally administrated with alcohol daily, continuously for one year. Through systematically analysis of all lipids in prefrontal cortex (PFC) and striatum region, we found that long-term alcohol exposure profoundly modified brain lipidome profiling. Notably, three kinds of lipid classes, glycerophospholipid (GP), glycerolipid (GL) and fatty acyls (FA), were significantly increased in these two brain regions. Interestingly, most of the modified lipids were involved in synthetic pathways of endoplasmic reticulum (ER), which may result in ER stress-related metabolic disruption. Moreover, alcohol-modified lipid species displayed long length of carbon chain with high degree of unsaturation. Taken together, our results firstly present that chronic alcohol exposure markedly modifies brain lipidomic profiling, which may activate ER stress and eventually result in neurotoxicity. These findings provide a new insight into the mechanism of alcohol-related brain damage. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Toxicology Letters
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3111 Biomedicine
dc.subject Alcohol abuse
dc.subject Lipidome profiling
dc.subject ER stress
dc.subject HOMEOSTASIS
dc.subject ACID
dc.subject ALZHEIMERS-DISEASE
dc.subject USE DISORDER
dc.subject ENDOPLASMIC-RETICULUM STRESS
dc.subject PROTECTS
dc.subject METABOLISM
dc.subject LIVER
dc.subject BURDEN
dc.subject CONSUMPTION
dc.title Chronic Alcohol Causes Alteration of Lipidome Profiling in Brain en
dc.type Article
dc.contributor.organization Institute of Biotechnology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.toxlet.2019.05.010
dc.relation.issn 0378-4274
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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