High risk in the first-trimester combined screening : Long-term outcomes of the children

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Äyräs , O , Rahkola-Soisalo , P , Kaijomaa , M , Tikkanen , M , Paavonen , J & Stefanovic , V 2019 , ' High risk in the first-trimester combined screening : Long-term outcomes of the children ' , European Journal of Obstetrics, and Gynecology ,and Reproductive Biology , vol. 237 , pp. 117-120 . https://doi.org/10.1016/j.ejogrb.2019.04.031

Title: High risk in the first-trimester combined screening : Long-term outcomes of the children
Author: Äyräs, Outi; Rahkola-Soisalo, Päivi; Kaijomaa, Marja; Tikkanen, Minna; Paavonen, Jorma; Stefanovic, Vedran
Contributor: University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, Department of Obstetrics and Gynecology
Date: 2019-06
Language: eng
Number of pages: 4
Belongs to series: European Journal of Obstetrics, and Gynecology ,and Reproductive Biology
ISSN: 0301-2115
URI: http://hdl.handle.net/10138/314997
Abstract: Objective: To bring new accuracy to the prognosis of outcomes of euploid fetuses with an extremely high risk in the first-trimester combined screening when compared to the low-risk group. Study design: The data included pregnancies with a trisomy 21 risk >= 1:50 in the combined first-trimester screening but normal fetal chromosomes. The control group had a risk value Results: The study comprised 483 women (161 cases and 322 controls). The mean follow-up time of children born alive was 61.4 months. An adverse outcome was detected in 11.8% of the cases and in 5.9% of the controls. After adjusting the values of mothers age, parity, and smoking habit the odds ratio for an adverse outcome was 2.1 (95% CI: 1.0-4.5, p = 0.05) for cases. When evaluating the effect of 1 SD increase in MOM of PAPP-A or 1 SD decrease in MOM of NT or beta-hCG to any adverse outcome, 1 SD increase in PAPP-A MOM decreased the risk of adverse outcome by OR 0.48 (95% CI: 0.3 - 0.8, p = 0.05) while the others were not significant. Conclusion: Euploid fetuses with a high risk in the combined first-trimester screening have a twofold risk for adverse outcomes when compared to those with a low risk. (C) 2019 Elsevier B.V. All rights reserved.
Subject: First-trimester screening
Outcome
Long-term follow-up
High-risk group
HUMAN CHORIONIC-GONADOTROPIN
INCREASED NUCHAL TRANSLUCENCY
PLASMA-PROTEIN-A
PAPP-A
PRETERM DELIVERY
PREGNANCY
BETA
ASSOCIATION
PREDICTION
TRISOMY-21
3123 Gynaecology and paediatrics
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