High risk in the first-trimester combined screening : Long-term outcomes of the children

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http://hdl.handle.net/10138/314997

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Äyräs , O , Rahkola-Soisalo , P , Kaijomaa , M , Tikkanen , M , Paavonen , J & Stefanovic , V 2019 , ' High risk in the first-trimester combined screening : Long-term outcomes of the children ' , European Journal of Obstetrics, and Gynecology ,and Reproductive Biology , vol. 237 , pp. 117-120 . https://doi.org/10.1016/j.ejogrb.2019.04.031

Title: High risk in the first-trimester combined screening : Long-term outcomes of the children
Author: Äyräs, Outi; Rahkola-Soisalo, Päivi; Kaijomaa, Marja; Tikkanen, Minna; Paavonen, Jorma; Stefanovic, Vedran
Contributor organization: Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
Clinicum
Date: 2019-06
Language: eng
Number of pages: 4
Belongs to series: European Journal of Obstetrics, and Gynecology ,and Reproductive Biology
ISSN: 0301-2115
DOI: https://doi.org/10.1016/j.ejogrb.2019.04.031
URI: http://hdl.handle.net/10138/314997
Abstract: Objective: To bring new accuracy to the prognosis of outcomes of euploid fetuses with an extremely high risk in the first-trimester combined screening when compared to the low-risk group. Study design: The data included pregnancies with a trisomy 21 risk >= 1:50 in the combined first-trimester screening but normal fetal chromosomes. The control group had a risk value Results: The study comprised 483 women (161 cases and 322 controls). The mean follow-up time of children born alive was 61.4 months. An adverse outcome was detected in 11.8% of the cases and in 5.9% of the controls. After adjusting the values of mothers age, parity, and smoking habit the odds ratio for an adverse outcome was 2.1 (95% CI: 1.0-4.5, p = 0.05) for cases. When evaluating the effect of 1 SD increase in MOM of PAPP-A or 1 SD decrease in MOM of NT or beta-hCG to any adverse outcome, 1 SD increase in PAPP-A MOM decreased the risk of adverse outcome by OR 0.48 (95% CI: 0.3 - 0.8, p = 0.05) while the others were not significant. Conclusion: Euploid fetuses with a high risk in the combined first-trimester screening have a twofold risk for adverse outcomes when compared to those with a low risk. (C) 2019 Elsevier B.V. All rights reserved.
Subject: First-trimester screening
Outcome
Long-term follow-up
High-risk group
HUMAN CHORIONIC-GONADOTROPIN
INCREASED NUCHAL TRANSLUCENCY
PLASMA-PROTEIN-A
PAPP-A
PRETERM DELIVERY
PREGNANCY
BETA
ASSOCIATION
PREDICTION
TRISOMY-21
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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