High risk in the first-trimester combined screening : Long-term outcomes of the children

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dc.contributor.author Äyräs, Outi
dc.contributor.author Rahkola-Soisalo, Päivi
dc.contributor.author Kaijomaa, Marja
dc.contributor.author Tikkanen, Minna
dc.contributor.author Paavonen, Jorma
dc.contributor.author Stefanovic, Vedran
dc.date.accessioned 2020-05-17T02:20:00Z
dc.date.available 2021-12-18T03:45:17Z
dc.date.issued 2019-06
dc.identifier.citation Äyräs , O , Rahkola-Soisalo , P , Kaijomaa , M , Tikkanen , M , Paavonen , J & Stefanovic , V 2019 , ' High risk in the first-trimester combined screening : Long-term outcomes of the children ' , European Journal of Obstetrics, and Gynecology ,and Reproductive Biology , vol. 237 , pp. 117-120 . https://doi.org/10.1016/j.ejogrb.2019.04.031
dc.identifier.other PURE: 126204457
dc.identifier.other PURE UUID: a48ea077-bd12-40f6-ad60-19a56a5f1f16
dc.identifier.other WOS: 000470953200021
dc.identifier.other ORCID: /0000-0001-7512-4823/work/60866052
dc.identifier.other ORCID: /0000-0003-4775-606X/work/68613369
dc.identifier.uri http://hdl.handle.net/10138/314997
dc.description.abstract Objective: To bring new accuracy to the prognosis of outcomes of euploid fetuses with an extremely high risk in the first-trimester combined screening when compared to the low-risk group. Study design: The data included pregnancies with a trisomy 21 risk >= 1:50 in the combined first-trimester screening but normal fetal chromosomes. The control group had a risk value Results: The study comprised 483 women (161 cases and 322 controls). The mean follow-up time of children born alive was 61.4 months. An adverse outcome was detected in 11.8% of the cases and in 5.9% of the controls. After adjusting the values of mothers age, parity, and smoking habit the odds ratio for an adverse outcome was 2.1 (95% CI: 1.0-4.5, p = 0.05) for cases. When evaluating the effect of 1 SD increase in MOM of PAPP-A or 1 SD decrease in MOM of NT or beta-hCG to any adverse outcome, 1 SD increase in PAPP-A MOM decreased the risk of adverse outcome by OR 0.48 (95% CI: 0.3 - 0.8, p = 0.05) while the others were not significant. Conclusion: Euploid fetuses with a high risk in the combined first-trimester screening have a twofold risk for adverse outcomes when compared to those with a low risk. (C) 2019 Elsevier B.V. All rights reserved. en
dc.format.extent 4
dc.language.iso eng
dc.relation.ispartof European Journal of Obstetrics, and Gynecology ,and Reproductive Biology
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject First-trimester screening
dc.subject Outcome
dc.subject Long-term follow-up
dc.subject High-risk group
dc.subject PAPP-A
dc.subject PREGNANCY
dc.subject BETA
dc.subject ASSOCIATION
dc.subject PREDICTION
dc.subject TRISOMY-21
dc.subject 3123 Gynaecology and paediatrics
dc.title High risk in the first-trimester combined screening : Long-term outcomes of the children en
dc.type Article
dc.contributor.organization Department of Obstetrics and Gynecology
dc.contributor.organization HUS Gynecology and Obstetrics
dc.contributor.organization Clinicum
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.ejogrb.2019.04.031
dc.relation.issn 0301-2115
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion
dc.type.version publishedVersion

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