A comparison of biologicals in the treatment of adults with severe asthma – real-life experiences

Show full item record



Permalink

http://hdl.handle.net/10138/315002

Citation

Asthma Research and Practice. 2020 May 13;6(1):2

Title: A comparison of biologicals in the treatment of adults with severe asthma – real-life experiences
Author: Kotisalmi, Emma; Hakulinen, Auli; Mäkelä, Mika; Toppila-Salmi, Sanna; Kauppi, Paula
Publisher: BioMed Central
Date: 2020-05-13
URI: http://hdl.handle.net/10138/315002
Abstract: Abstract Background Anti-IgE (omalizumab) and anti-IL5/IL5R (reslizumab, mepolizumab and benralizumab) treatments are available for severe allergic and eosinophilic asthma. In these patients, studies have shown beneficial effects in oral corticosteroid use and exacerbations. The aim of this retrospective single-center study was to evaluate the effect of biological therapy on severe asthma and to compare different therapies. Methods We collected and analysed results of anti-IL5/IL5R and anti-IgE therapies for asthma from January 2009 until October 2019 in specialized care. We compared number of exacerbations, asthma symptoms and use of per oral corticosteroids and antimicrobics because of asthma before and during biological therapy, and in a separate analysis need for per oral corticosteroids, antimicrobics or surgery due to upper respiratory tract diseases in asthmatics receiving biologicals. The analyses were done using the Chi square test, T-test or Mann-Whitney U -test, the Kruskall-Wallis test or the Wilcoxon test. Results Of 64 patients, 40 used continuous per oral corticosteroid therapy prior to biological therapy. The mean daily dose of per oral corticosteroid was reduced in those with anti-IL5/IL5R therapy (− 3.0 mg, p = 0.02). The number of annual per oral corticosteroid courses decreased in both the anti-IL5/IL5R (− 2.8 courses, p < 0.05) and anti-IgE groups (− 1.3 courses, p < 0.05). The number of annual antibiotic courses (− 0.7 courses, p = 0.04) and total number of exacerbation events (− 4.4 events/year, p < 0.05) were reduced in the anti-IL5/IL5R group. In the 55 asthma patients analysed for upper respiratory tract findings, the results suggested a reduction in need for chronic rhinosinusitis surgery during biological therapy. Conclusions Results with biological therapies in this real-life clinical setting are comparable to those reported in clinical trials. Biological therapy reduces exacerbations and per oral corticosteroid use. Trial registration NCT04158050, retrospectively registered 6.11.2019.
Subject: Anti-IgE
Anti-IL5
Asthma
Biological therapy
Corticosteroid
Eosinophils
Exacerbation
IgE
Chronic rhinosinusitis


Files in this item

Total number of downloads: Loading...

Files Size Format View
40733_2020_Article_55.pdf 696.6Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record