Increase in Childhood Nontuberculous Mycobacterial Infections After Bacille Calmette-Guerin Coverage Drop : A Nationwide, Population-Based Retrospective Study, Finland, 1995-2016

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Kontturi , A , Soini , H , Ollgren , J & Salo , E 2018 , ' Increase in Childhood Nontuberculous Mycobacterial Infections After Bacille Calmette-Guerin Coverage Drop : A Nationwide, Population-Based Retrospective Study, Finland, 1995-2016 ' , Clinical Infectious Diseases , vol. 67 , no. 8 , pp. 1256-1261 . https://doi.org/10.1093/cid/ciy241

Title: Increase in Childhood Nontuberculous Mycobacterial Infections After Bacille Calmette-Guerin Coverage Drop : A Nationwide, Population-Based Retrospective Study, Finland, 1995-2016
Author: Kontturi, Antti; Soini, Hanna; Ollgren, Jukka; Salo, Eeva
Contributor: University of Helsinki, Children's Hospital
University of Helsinki, Clinicum
Date: 2018-10-15
Language: eng
Number of pages: 6
Belongs to series: Clinical Infectious Diseases
ISSN: 1058-4838
URI: http://hdl.handle.net/10138/315018
Abstract: Background. Epidemiological data on childhood nontuberculous mycobacterial (NTM) disease is scarce and the protective effect of bacille Calmette-Guerin (BCG) vaccination remains debated. In 2006, the BCG policy in Finland changed from universal to selective. We aimed to study the effect of the BCG coverage decrease on the incidence of childhood NTM infections in Finland. Methods. We conducted a nationwide, population-based, retrospective study of NTM notifications recorded to the National Infectious Diseases Register between 1995 and 2016 and identified native-born children aged 0-4 years infected with NTM. Poisson log-linear model was used to estimate the change in the incidence rate of cohorts born during universal or selective BCG policy between 1995 and 2015. Results. We identified 97 native-born children aged Conclusions. After infant BCG coverage in Finland decreased, childhood NTM infections increased drastically. As there is no other apparent cause for the increase, this indicates that BCG offers protection against childhood NTM disease. 'phis observation adds to the understanding of childhood NTM epidemiology and might explain why the disease is emerging in some countries.
Subject: nontuberculous mycobacteria
NTM
lymphadenitis
BCG
vaccination coverage
BCG-VACCINATION
CHILDREN
LYMPHADENITIS
TUBERCULOSIS
SURVEILLANCE
NETHERLANDS
DIAGNOSIS
VACCINES
DISEASE
WATERS
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
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