Complete Atrioventricular Septal Defect : Evolution of Results in a Single Center During 50 Years

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dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Children's Hospital en
dc.contributor University of Helsinki, Lastentautien yksikkö en
dc.contributor University of Helsinki, Children's Hospital en
dc.contributor University of Helsinki, Children's Hospital en
dc.contributor University of Helsinki, HUS Children and Adolescents en
dc.contributor University of Helsinki, Children's Hospital en
dc.contributor University of Helsinki, Children's Hospital en
dc.contributor University of Helsinki, HUS Children and Adolescents en
dc.contributor University of Helsinki, HUS Children and Adolescents en
dc.contributor.author Airaksinen, Riku
dc.contributor.author Mattila, Ilkka
dc.contributor.author Jokinen, Eero
dc.contributor.author Salminen, Jukka
dc.contributor.author Puntila, Juha
dc.contributor.author Lehtinen, Miia L.
dc.contributor.author Ojala, Tilna
dc.contributor.author Rautiainen, Paula
dc.contributor.author Rahkonen, Otto
dc.contributor.author Suominen, Pertti
dc.contributor.author Pätilä, Tommi
dc.date.accessioned 2020-05-22T01:10:27Z
dc.date.available 2020-07-05T21:01:54Z
dc.date.issued 2019-06
dc.identifier.citation Airaksinen , R , Mattila , I , Jokinen , E , Salminen , J , Puntila , J , Lehtinen , M L , Ojala , T , Rautiainen , P , Rahkonen , O , Suominen , P & Pätilä , T 2019 , ' Complete Atrioventricular Septal Defect : Evolution of Results in a Single Center During 50 Years ' , Annals of Thoracic Surgery , vol. 107 , no. 6 , pp. 1824-1830 . https://doi.org/10.1016/j.athoracsur.2019.01.020 en
dc.identifier.issn 0003-4975
dc.identifier.other PURE: 125465170
dc.identifier.other PURE UUID: 672ea149-95a1-4f62-9502-213a41e13e51
dc.identifier.other WOS: 000468608200055
dc.identifier.uri http://hdl.handle.net/10138/315094
dc.description.abstract Background. Operative mortality after complete atrioventricular septal defect (cAVSD) repair has improved vastly. Less improvement has been demonstrated regarding late mortality and reoperation rates, however. There is evident lack of comprehensive population-based studies analyzing the history and progress of the ever-changing operative results. Methods. This is a 5-million population-based retrospective study of consecutive 388 cAVSD patients operated in Finland between 1962 and 2014. Data were collected using Children's Cardiac Surgical Registry of Children's Hospital at the Helsinki University Hospital, Finland. Mortality data and reoperation rates were analyzed on a decade-by-decade basis. Results. During the early era, overall mortality was 17.4%, operative mortality constituting 10.9%. The operative results have improved significantly over the decades, and eventually, the last decade showed no mortality. A total of 23 late deaths occurred; of these, 20 were directly heart-related. Half of the late mortality occurred during the first postoperative year. The only significant risk factor for overall mortality was an earlier decade of operation (p <0.001). Reoperation rates have not decreased but slightly increased over decades (p = 0.621), and reoperations have been performed mainly during the first year after the primary operation. Actuarial freedom from left side atrioventricular valve reoperation at 15 years was 90.9%. Conclusions. There has been an outstanding improvement in surgical results through the years even though the general operative approach has remained the same. Rates of reoperation have not been declining, but the reoperations are dated to early childhood years. The improvement in results has been ongoing. (C) 2019 by The Society of Thoracic Surgeons en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Annals of Thoracic Surgery
dc.rights en
dc.subject SURGICAL REPAIR en
dc.subject DOWN-SYNDROME en
dc.subject OUTCOMES en
dc.subject SOCIETY en
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology en
dc.title Complete Atrioventricular Septal Defect : Evolution of Results in a Single Center During 50 Years en
dc.type Article
dc.description.version Peer reviewed
dc.date.embargoedUntil 2020-05-22
dc.identifier.doi https://doi.org/10.1016/j.athoracsur.2019.01.020
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/acceptedVersion
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