Summary statistics for drug concentrations in post-mortem femoral blood representing all causes of death

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http://hdl.handle.net/10138/315208

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Ketola , R A & Ojanperä , I 2019 , ' Summary statistics for drug concentrations in post-mortem femoral blood representing all causes of death ' , Drug Testing and Analysis , vol. 11 , no. 9 , pp. 1326-1337 . https://doi.org/10.1002/dta.2655

Title: Summary statistics for drug concentrations in post-mortem femoral blood representing all causes of death
Author: Ketola, Raimo A.; Ojanperä, Ilkka
Contributor organization: Department of Forensic Medicine
Date: 2019-09
Language: eng
Number of pages: 12
Belongs to series: Drug Testing and Analysis
ISSN: 1942-7603
DOI: https://doi.org/10.1002/dta.2655
URI: http://hdl.handle.net/10138/315208
Abstract: Concentration distributions for 183 drugs and metabolites frequently found in post-mortem (PM) femoral venous blood were statistically characterized based on an extensive database of 122 234 autopsy cases investigated during an 18-year period in a centralized laboratory. The cases represented all causes of death, with fatal drug poisonings accounting for 8%. The proportion of males was 74% with a median age of 58 years compared with 26% females with a median age of 64 years. In 36% of these cases, blood alcohol concentration was higher than or equal to 0.2 parts per thousand, the median being 1.6 parts per thousand. The mean, median, and upper percentile (90th, 95th, 97.5th) drug concentrations were established, as the median PM concentrations give an idea of the "normal" PM concentration level, and the upper percentile concentrations indicate possible overdose levels. A correspondence was found between subsets of the present and the previously published PM drug concentrations from another laboratory that grouped cases according to the cause of death. Our results add to the knowledge for evidence-based interpretation of drug-related deaths.
Subject: cause of death
drug concentration
post-mortem blood
post-mortem drug redistribution
post-mortem toxicology
GAS-CHROMATOGRAPHY
HUMAN PLASMA
LC-MS/MS
PHARMACOKINETICS
METABOLITES
BENZODIAZEPINES
BUPRENORPHINE
COMPILATION
VOLUNTEERS
POISONINGS
319 Forensic science and other medical sciences
1182 Biochemistry, cell and molecular biology
116 Chemical sciences
317 Pharmacy
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion


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